Translocation of c-sis protooncogene in peripheral neuroepithelioma

Carol J. Thiele, Jacqueline Whang-Peng, Chien Song Kao-Shan, James Miser, Mark A. Israel

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16 Citations (Scopus)


Molecular genetic analysis of the c-sis protooncogene was performed on two neuroepithelioma cell lines carrying a t(11;22)(q24;q12). The c-sis protooncogene was found by in situ hybridization to be translocated from its germline position on chromosome #22 to the derivative chromosome #11 in each cell line. However, it was not rearranged or amplified in either cell line examined. In addition, we did not detect c-sis transcripts in Northern blots of poly (A)+ RNA. This is similar to results found in Ewing's sarcoma, which carries a cytogenetically indistinguishable translocation from neuroepithelioma.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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