TY - JOUR
T1 - Translocation of c-sis protooncogene in peripheral neuroepithelioma
AU - Thiele, Carol J.
AU - Whang-Peng, Jacqueline
AU - Kao-Shan, Chien Song
AU - Miser, James
AU - Israel, Mark A.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Molecular genetic analysis of the c-sis protooncogene was performed on two neuroepithelioma cell lines carrying a t(11;22)(q24;q12). The c-sis protooncogene was found by in situ hybridization to be translocated from its germline position on chromosome #22 to the derivative chromosome #11 in each cell line. However, it was not rearranged or amplified in either cell line examined. In addition, we did not detect c-sis transcripts in Northern blots of poly (A)+ RNA. This is similar to results found in Ewing's sarcoma, which carries a cytogenetically indistinguishable translocation from neuroepithelioma.
AB - Molecular genetic analysis of the c-sis protooncogene was performed on two neuroepithelioma cell lines carrying a t(11;22)(q24;q12). The c-sis protooncogene was found by in situ hybridization to be translocated from its germline position on chromosome #22 to the derivative chromosome #11 in each cell line. However, it was not rearranged or amplified in either cell line examined. In addition, we did not detect c-sis transcripts in Northern blots of poly (A)+ RNA. This is similar to results found in Ewing's sarcoma, which carries a cytogenetically indistinguishable translocation from neuroepithelioma.
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U2 - 10.1016/0165-4608(87)90088-4
DO - 10.1016/0165-4608(87)90088-4
M3 - Article
C2 - 3791169
AN - SCOPUS:0023242548
SN - 0165-4608
VL - 24
SP - 119
EP - 128
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
