Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

Chi Mei Wang; Shan Jen Li; Chi Hao Wu; Chien Ming Hu; Hui Wen Cheng; Jung Su Chang

doi:10.7314/APJCP.2014.15.2.605

Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

Chi Mei Wang, Shan Jen Li, Chi Hao Wu, Chien Ming Hu, Hui Wen Cheng, Jung Su Chang

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

Original language	English
Pages (from-to)	605-610
Number of pages	6
Journal	Asian Pacific Journal of Cancer Prevention
Volume	15
Issue number	2
DOIs	https://doi.org/10.7314/APJCP.2014.15.2.605
Publication status	Published - 2014

Keywords

Endoplasmic reticulum stress
Grp78
Hepatic stellate cells
Liver fibrosis
Serum ferritin

ASJC Scopus subject areas

Oncology
Cancer Research
Public Health, Environmental and Occupational Health
Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7314/APJCP.2014.15.2.605

Cite this

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abstract = "Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p",

keywords = "Endoplasmic reticulum stress, Grp78, Hepatic stellate cells, Liver fibrosis, Serum ferritin",

author = "Wang, {Chi Mei} and Li, {Shan Jen} and Wu, {Chi Hao} and Hu, {Chien Ming} and Cheng, {Hui Wen} and Chang, {Jung Su}",

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T1 - Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

AU - Wang, Chi Mei

AU - Li, Shan Jen

AU - Wu, Chi Hao

AU - Hu, Chien Ming

AU - Cheng, Hui Wen

AU - Chang, Jung Su

PY - 2014

Y1 - 2014

N2 - Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

AB - Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

KW - Endoplasmic reticulum stress

KW - Grp78

KW - Hepatic stellate cells

KW - Liver fibrosis

KW - Serum ferritin

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Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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