Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential

Ngoc Bao An Nguyen, Lo Yun Chen, Mohamed El-Shazly, Bo Rong Peng, Jui Hsin Su, Ho Cheng Wu, I. Ta Lee, Kuei Hung Lai

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022. Various types of diterpenes (eunicellins, cembranes, spatanes, norcembranes, briaranes, and aquarianes), as well as biscembranes, sterols, and quinones were discovered and subjected to bioactivity investigations in 53 different studies. We also introduce a more in-depth discussion of the potential biological effects (anti-cancer, anti-inflammatory, and anti-microbial) and the mechanisms of action of the identified secondary metabolites. We hope this review will shed light on the untapped potential applications of aquaculture to produce valuable secondary metabolites to tackle current and emerging health conditions.

Original languageEnglish
Article number640
JournalMarine Drugs
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2022

Keywords

  • biological functions
  • cultured soft corals
  • drug developments
  • medicinal resource
  • secondary metabolites

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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