Total synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

Sheng Tung Huang; Hsien-Saw Kuo; Chien Tsu Chen

doi:10.1016/S0040-4039(01)01580-5

Total synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

Sheng Tung Huang, Hsien-Saw Kuo, Chien Tsu Chen

Department of Biochemistry and Molecular Cell Biology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Concise synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone (1) and its analogue (2) are reported. Natural products 1 and 2 were prepared in four and five steps, respectively, from 5-bromosalicylaldehyde.

Original language	English
Pages (from-to)	7473-7475
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(01)01580-5
Publication status	Published - Oct 15 2001

Keywords

1-benzoxepine
NADH:ubiquinone oxidoreductase
Pterulone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01580-5

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title = "Total synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue",

abstract = "Concise synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone (1) and its analogue (2) are reported. Natural products 1 and 2 were prepared in four and five steps, respectively, from 5-bromosalicylaldehyde.",

keywords = "1-benzoxepine, NADH:ubiquinone oxidoreductase, Pterulone",

author = "Huang, {Sheng Tung} and Hsien-Saw Kuo and Chen, {Chien Tsu}",

note = "Funding Information: We thank Nation Science Council (NSC 89-2113-M-038-007) for generous financial support of this research. We also would like to thank Dr. Andrew Maioli for this manuscript correction.",

year = "2001",

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doi = "10.1016/S0040-4039(01)01580-5",

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T1 - Total synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

AU - Huang, Sheng Tung

AU - Kuo, Hsien-Saw

AU - Chen, Chien Tsu

N1 - Funding Information: We thank Nation Science Council (NSC 89-2113-M-038-007) for generous financial support of this research. We also would like to thank Dr. Andrew Maioli for this manuscript correction.

PY - 2001/10/15

Y1 - 2001/10/15

N2 - Concise synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone (1) and its analogue (2) are reported. Natural products 1 and 2 were prepared in four and five steps, respectively, from 5-bromosalicylaldehyde.

AB - Concise synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone (1) and its analogue (2) are reported. Natural products 1 and 2 were prepared in four and five steps, respectively, from 5-bromosalicylaldehyde.

KW - 1-benzoxepine

KW - NADH:ubiquinone oxidoreductase

KW - Pterulone

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Total synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

Abstract

Keywords

ASJC Scopus subject areas

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