Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin; Chia Wen Ho; Leroy F. Liu; Yi Lisa Lyu

doi:10.1074/jbc.M112.415471

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin, Chia Wen Ho, Leroy F. Liu, Yi Lisa Lyu

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

Original language	English
Pages (from-to)	7182-7192
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.415471
Publication status	Published - Mar 8 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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title = "Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis",

abstract = "Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.",

author = "Lin, {Ren Kuo} and Ho, {Chia Wen} and Liu, {Leroy F.} and Lyu, {Yi Lisa}",

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AU - Lin, Ren Kuo

AU - Ho, Chia Wen

AU - Liu, Leroy F.

AU - Lyu, Yi Lisa

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

AB - Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

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JF - Journal of Biological Chemistry

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Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Abstract

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