TMC-151 a monoacetate, a new polyketide from Bionectria ochroleuca

Yu Ming Ju; Shin Hun Juang; Ke Jun Chen; Zong-Huei Li

doi:10.1515/znb-2007-0412

TMC-151 a monoacetate, a new polyketide from Bionectria ochroleuca

Yu Ming Ju, Shin Hun Juang, Ke Jun Chen, Zong-Huei Li

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A new polyketide, TMC-151 A monoacetate (1), along with a known analogue, TMC-151 F (2), was isolated from ethyl acetate extracts of the fermentation broth of Bionectria ochroleuca isolated in Taiwan. Their structures were elucidated on the basis of spectroscopic analysis. The antiproliferative activities of 1 and 2 were evaluated against MT-2 (human leukemia), A498 (human renal carcinoma), NPC-tw01 (human nasopharyngeal carcinoma), H-226 and A549 (non-small cell lung cancer) cell lines, and their IC₅₀ values ranged from 18.3 to 40.2 μM.

Original language	English
Pages (from-to)	561-564
Number of pages	4
Journal	Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume	62
Issue number	4
DOIs	https://doi.org/10.1515/znb-2007-0412
Publication status	Published - Apr 2007

Keywords

Bionectria ochroleuca
Cytotoxicity
Fermentation broth
Hypocreales
Polyketides

ASJC Scopus subject areas

Inorganic Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/znb-2007-0412

Cite this

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abstract = "A new polyketide, TMC-151 A monoacetate (1), along with a known analogue, TMC-151 F (2), was isolated from ethyl acetate extracts of the fermentation broth of Bionectria ochroleuca isolated in Taiwan. Their structures were elucidated on the basis of spectroscopic analysis. The antiproliferative activities of 1 and 2 were evaluated against MT-2 (human leukemia), A498 (human renal carcinoma), NPC-tw01 (human nasopharyngeal carcinoma), H-226 and A549 (non-small cell lung cancer) cell lines, and their IC50 values ranged from 18.3 to 40.2 μM.",

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AU - Ju, Yu Ming

AU - Juang, Shin Hun

AU - Chen, Ke Jun

AU - Li, Zong-Huei

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AB - A new polyketide, TMC-151 A monoacetate (1), along with a known analogue, TMC-151 F (2), was isolated from ethyl acetate extracts of the fermentation broth of Bionectria ochroleuca isolated in Taiwan. Their structures were elucidated on the basis of spectroscopic analysis. The antiproliferative activities of 1 and 2 were evaluated against MT-2 (human leukemia), A498 (human renal carcinoma), NPC-tw01 (human nasopharyngeal carcinoma), H-226 and A549 (non-small cell lung cancer) cell lines, and their IC50 values ranged from 18.3 to 40.2 μM.

KW - Bionectria ochroleuca

KW - Cytotoxicity

KW - Fermentation broth

KW - Hypocreales

KW - Polyketides

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TMC-151 a monoacetate, a new polyketide from Bionectria ochroleuca

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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