Because of the physical, chemical, and biological properties of polylactic acid
(PLA), it is a potential material for orthopedic surgery. To study the tissue response to and degradation of PLA in bone tissue. The materials used included PLA bone screws and plates which were composed of 5% D-form and 95% L-form polylactide.
Custom-made bone screws, bars, and plates were studied, using commercial
products as controls. The materials were implanted into 24 New Zealand white
rabbits by optimal methods and removed after 1, 4, 8, and 12 weeks for histological and physical examination. The tissue response revealed good biocompatibility. There was no difference in weight loss with an increase in time. The bending load and molecular weight decreased with an increase in time. The initial bending load of the commercial plate was stronger and significantly decreased with an increase in time. The bending load of the custom-made products was more stable than that of the commercial products. It is clear that the bending load decreased as the molecular weight decreased during the degradation process. However, there was no simultaneous weight loss. It is evident that the custom-made plates produced by injection-molded had a lower molecular weight but maintained adequate strength for as long as did the commercial plates. These results suggest that the selfmanufactured
screws and plates have good bone tissue reaction. The custom-made
PLA products had higher strength with a similar molecular weight. They underwent the same degradation process as commercial products. In addition, they can shift the load to the healing bone as time passes. They thus meet the demands of ideal orthopedic devices.
Translated title of the contribution聚乳酸系骨釘骨板之組織反應與降解變化
Original languageEnglish
Pages (from-to)209-220
Number of pages12
Issue number3
Publication statusPublished - 2003


  • Polylactic acid
  • Bone screw
  • Bone plate
  • Biocompatibility
  • Biodegradable


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