Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

Mei Chuan Tang; Li Chuan Chan; Yi Chen Yeh; Cheng Yu Chen; Teh Ying Chou; Wei Shu Wang; Yeu Su

doi:10.1016/j.canlet.2011.05.001

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

Mei Chuan Tang, Li Chuan Chan, Yi Chen Yeh, Cheng Yu Chen, Teh Ying Chou, Wei Shu Wang, Yeu Su

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Thymosin β₄ (Tβ₄) overexpression increases cell migration and tumor metastasis. Hence, understanding the mechanism of cancer cell migration induced by Tβ₄ may provide means to inhibit their metastasis. We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ₄-overexpressing SW480 cells. In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ₄ simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability. These findings suggest that Tβ₄ increases migration of colon cancer cells via activating Rac1 by elevating IQGAP1/ILK complexes and IHC results illustrated a similar mechanism occurring in vivo.

Original language	English
Pages (from-to)	162-171
Number of pages	10
Journal	Cancer Letters
Volume	308
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2011.05.001
Publication status	Published - Sept 28 2011
Externally published	Yes

Keywords

ILK
IQGAP1
Migration
Rac1
Thymosin β4 (Tβ4)

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.canlet.2011.05.001

Cite this

@article{5192c2dbf71b4f3b94275aee3d14940b,

title = "Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway",

abstract = "Thymosin β4 (Tβ4) overexpression increases cell migration and tumor metastasis. Hence, understanding the mechanism of cancer cell migration induced by Tβ4 may provide means to inhibit their metastasis. We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ4-overexpressing SW480 cells. In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ4 simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability. These findings suggest that Tβ4 increases migration of colon cancer cells via activating Rac1 by elevating IQGAP1/ILK complexes and IHC results illustrated a similar mechanism occurring in vivo.",

keywords = "ILK, IQGAP1, Migration, Rac1, Thymosin β4 (Tβ4)",

author = "Tang, {Mei Chuan} and Chan, {Li Chuan} and Yeh, {Yi Chen} and Chen, {Cheng Yu} and Chou, {Teh Ying} and Wang, {Wei Shu} and Yeu Su",

year = "2011",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2011.05.001",

language = "English",

volume = "308",

pages = "162--171",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

AU - Tang, Mei Chuan

AU - Chan, Li Chuan

AU - Yeh, Yi Chen

AU - Chen, Cheng Yu

AU - Chou, Teh Ying

AU - Wang, Wei Shu

AU - Su, Yeu

PY - 2011/9/28

Y1 - 2011/9/28

N2 - Thymosin β4 (Tβ4) overexpression increases cell migration and tumor metastasis. Hence, understanding the mechanism of cancer cell migration induced by Tβ4 may provide means to inhibit their metastasis. We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ4-overexpressing SW480 cells. In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ4 simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability. These findings suggest that Tβ4 increases migration of colon cancer cells via activating Rac1 by elevating IQGAP1/ILK complexes and IHC results illustrated a similar mechanism occurring in vivo.

AB - Thymosin β4 (Tβ4) overexpression increases cell migration and tumor metastasis. Hence, understanding the mechanism of cancer cell migration induced by Tβ4 may provide means to inhibit their metastasis. We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ4-overexpressing SW480 cells. In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ4 simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability. These findings suggest that Tβ4 increases migration of colon cancer cells via activating Rac1 by elevating IQGAP1/ILK complexes and IHC results illustrated a similar mechanism occurring in vivo.

KW - ILK

KW - IQGAP1

KW - Migration

KW - Rac1

KW - Thymosin β4 (Tβ4)

UR - http://www.scopus.com/inward/record.url?scp=80051817916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051817916&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2011.05.001

DO - 10.1016/j.canlet.2011.05.001

M3 - Article

C2 - 21621326

AN - SCOPUS:80051817916

SN - 0304-3835

VL - 308

SP - 162

EP - 171

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this