Thrombopoietic cytokines in patients with hepatitis C virus-associated immune thrombocytopenia

Cih En Huang, Yi Yang Chen, Jung Jung Chang, Feng Che Kuan, Kuan Der Lee, Chang Hsien Lu, Jrhau Lung, Chien Heng Shen, Chih Cheng Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objectives: Complex and multiple mechanisms are involved in the etiology of Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP). Many hematopoietic growth factors affect the thrombopoiesis. The aim of this study was to clarify the interaction of the thrombopoietic factors in patients with HCV-ITP. Methods: We selected 33 patients with HCV-ITP and 17 normal individuals. We compare serum interleukin (IL)-3, IL-6, IL-11, thrombopoietin (Tpo), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-α (TNFα), and spleen size between these two groups. Results: Our study shows that Tpo, IL-6, and TNFα significantly increased in patients with HCV-ITP compared to the normal population (Tpo:122.577 vs. 40.602; IL-6: 2.175 vs. 0.943; TNFα: 2.460 vs. 1.322). IL-11 was significantly lower in the HCV-ITP group (10.829 vs. 15.042). HCV-ITP patients had a higher spleen index (21.121 vs 13.498, P = 0.003). According to regression analysis and multiple linear regression analysis, only IL-11 had a significantly positive correlation with platelet count, while TNFα showed a negative correlation. Discussions: Tpo and IL-6 increased in patients with HCV-ITP, suggesting a positive feedback of low platelet count. TNFα-associated immune response is suspected to have an impact on low platelet count. IL-11 is assumed to directly affect thrombopoiesis. Conclusions: This study is the most comprehensive study to evaluate the interaction between platelet count and the important thrombopoetic factors in patients with HCV-ITP. The thrombopoietic factors clearly play an important role in HCV-ITP.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
Issue number1
Publication statusPublished - Jan 2 2017
Externally publishedYes


  • Cytokine
  • Hepatitis C
  • Immune thrombocytopenia
  • Interleukin
  • Spleen
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


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