Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines

Chi I. Chang; Ching Chuan Kuo; Jang Yang Chang; Yueh Hsiung Kuo

doi:10.1021/np030267m

Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines

Chi I. Chang, Ching Chuan Kuo, Jang Yang Chang, Yueh Hsiung Kuo

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC₅₀ values in the range 1.2-3.6 μM.

Original language	English
Pages (from-to)	91-93
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	1
DOIs	https://doi.org/10.1021/np030267m
Publication status	Published - Jan 2004
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np030267m

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abstract = "Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 μM.",

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AU - Kuo, Yueh Hsiung

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AB - Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 μM.

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Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines

Abstract

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