Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines

Chi I. Chang, Ching Chuan Kuo, Jang Yang Chang, Yueh Hsiung Kuo

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 μM.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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