Third and second harmonic generation imaging of human articular cartilage

Ming Rung Tsai, Chih-Hwa Chen, Chi Kuang Sun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)


Cartilage matrix is damaged in diseased states such as osteoarthritis while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 2009
Externally publishedYes
EventMultiphoton Microscopy in the Biomedical Sciences IX - San Jose, CA, United States
Duration: Jan 25 2009Jan 27 2009


OtherMultiphoton Microscopy in the Biomedical Sciences IX
Country/TerritoryUnited States
CitySan Jose, CA


  • 3D microscopy
  • Articular cartilage
  • Chondrocyte
  • Harmonic generation microscopy

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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