Abstract
Cartilage matrix is damaged in diseased states such as osteoarthritis while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.
| Original language | English |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 7183 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
| Event | Multiphoton Microscopy in the Biomedical Sciences IX - San Jose, CA, United States Duration: Jan 25 2009 → Jan 27 2009 |
Other
| Other | Multiphoton Microscopy in the Biomedical Sciences IX |
|---|---|
| Country/Territory | United States |
| City | San Jose, CA |
| Period | 1/25/09 → 1/27/09 |
Keywords
- 3D microscopy
- Articular cartilage
- Chondrocyte
- Harmonic generation microscopy
ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
