Thermal Perception Abnormalities Can Predict Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Wei Ching Fang, Kuei Mei Chou, Chiao Yin Sun, Chin Chan Lee, I. Wen Wu, Yung Chang Chen, Heng Chih Pan

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: Previous studies have illustrated clinical associations between diabetic peripheral neuropathy (DPN) and diabetic kidney disease (DKD). Quantitative sensory testing (QST) can accurately detect thermal perception abnormalities and aid in the early diagnosis of asymptomatic small-fiber DPN in patients with type 2 diabetes. The aim of this study was to determine the predictive value of thermal perception abnormalities by QST to detect DKD. Methods: We prospectively enrolled 432 patients with type 2 diabetes (50.2% male, mean age 57.2 years, and average duration of diabetes 9.9 years) at our hospital between 2016 and 2017. Demographic and clinical data of the patients were recorded and analyzed. Diagnosis and staging of DKD were determined by urinary albumin excretion rate and estimated glomerular filtration rate. The presence of thermal perception abnormalities was determined by QST. Multiple logistic regression and receiver operating characteristic (ROC) analyses were performed to investigate the relationships between thermal perception abnormalities and DKD in these patients. Results: In multiple regression analysis, abnormal cold perception in the lower limbs was associated with an increased risk of advanced DKD. Area under the ROC curve analysis revealed that four-limb cold perception abnormalities had the best discriminatory power (0.741 ± 0.053) to predict advanced DKD. Conclusions: Our results demonstrate the value of using thermal perception abnormalities to identify patients with type 2 diabetes also at risk of DKD.

Original languageEnglish
Pages (from-to)926-938
Number of pages13
JournalKidney and Blood Pressure Research
Issue number6
Publication statusPublished - Dec 2020
Externally publishedYes


  • Diabetic kidney disease
  • Diabetic neuropathy
  • Quantitative sensory test
  • Thermal perception abnormalities
  • Type 2 diabetes

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Thermal Perception Abnormalities Can Predict Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients'. Together they form a unique fingerprint.

Cite this