Therapeutic applications of resveratrol and its derivatives on periodontitis

Yu Tang Chin, Guei Yun Cheng, Ya Jung Shih, Chi Yu Lin, Shan Jen Lin, Hsuan Yu Lai, Jacqueline Whang-Peng, Hsien Chung Chiu, Sheng Yang Lee, Earl Fu, Heng Yuan Tang, Hung Yun Lin, Leroy F. Liu

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalAnnals of the New York Academy of Sciences
Issue number1
Publication statusPublished - Sept 1 2017


  • antioxidant
  • inflammation
  • oxidative stress
  • periodontitis
  • resveratrol

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


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