Therapeutic applications of resveratrol and its derivatives on periodontitis

Yu Tang Chin; Guei Yun Cheng; Ya Jung Shih; Chi Yu Lin; Shan Jen Lin; Hsuan Yu Lai; Jacqueline Whang-Peng; Hsien Chung Chiu; Sheng Yang Lee; Earl Fu; Heng Yuan Tang; Hung Yun Lin; Leroy F. Liu

doi:10.1111/nyas.13433

Therapeutic applications of resveratrol and its derivatives on periodontitis

Yu Tang Chin, Guei Yun Cheng, Ya Jung Shih, Chi Yu Lin, Shan Jen Lin, Hsuan Yu Lai, Jacqueline Whang-Peng, Hsien Chung Chiu, Sheng Yang Lee, Earl Fu, Heng Yuan Tang, Hung Yun Lin, Leroy F. Liu

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	1403
Issue number	1
DOIs	https://doi.org/10.1111/nyas.13433
Publication status	Published - Sept 1 2017

Keywords

antioxidant
inflammation
oxidative stress
periodontitis
resveratrol

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/nyas.13433

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title = "Therapeutic applications of resveratrol and its derivatives on periodontitis",

abstract = "Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.",

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AU - Chin, Yu Tang

AU - Cheng, Guei Yun

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AU - Lin, Shan Jen

AU - Lai, Hsuan Yu

AU - Whang-Peng, Jacqueline

AU - Chiu, Hsien Chung

AU - Lee, Sheng Yang

AU - Fu, Earl

AU - Tang, Heng Yuan

AU - Lin, Hung Yun

AU - Liu, Leroy F.

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N2 - Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.

AB - Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.

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Therapeutic applications of resveratrol and its derivatives on periodontitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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