The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

I. Ching Chou; Fuu Jen Tsai; Chao Ching Huang; Cheng Chieh Lin; Chang Hai Tsai

The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

I. Ching Chou, Fuu Jen Tsai, Chao Ching Huang, Cheng Chieh Lin, Chang Hai Tsai

Research output: Contribution to journal › Article › peer-review

Abstract

Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

Original language	English
Pages (from-to)	1971-1973
Number of pages	3
Journal	NeuroReport
Volume	13
Issue number	15
Publication status	Published - Oct 28 2002
Externally published	Yes

Keywords

Febrile convulsion
KCNQ2
Polymorphism
Voltage-gated potassium channel

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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abstract = "Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.",

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T1 - The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

AU - Chou, I. Ching

AU - Tsai, Fuu Jen

AU - Huang, Chao Ching

AU - Lin, Cheng Chieh

AU - Tsai, Chang Hai

PY - 2002/10/28

Y1 - 2002/10/28

N2 - Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

AB - Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

KW - Febrile convulsion

KW - KCNQ2

KW - Polymorphism

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The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

Abstract

Keywords

ASJC Scopus subject areas

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