The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

I. Ching Chou, Fuu Jen Tsai, Chao Ching Huang, Cheng Chieh Lin, Chang Hai Tsai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

Original languageEnglish
Pages (from-to)1971-1973
Number of pages3
JournalNeuroReport
Volume13
Issue number15
Publication statusPublished - Oct 28 2002
Externally publishedYes

Keywords

  • Febrile convulsion
  • KCNQ2
  • Polymorphism
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Neuroscience(all)

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