TY - JOUR
T1 - The value of human growth hormone as an adjuvant for ovarian stimulation in a human in vitro fertilization program
AU - Wu, Ming Yih
AU - Chen, Hsin Fu
AU - Ho, Hong Nerng
AU - Chen, Shee Uan
AU - Chao, Kuang Han
AU - Huang, Su Cheng
AU - Lee, Tzu Yao
AU - Yang, Yu Shih
PY - 1996/1/1
Y1 - 1996/1/1
N2 - The purpose of this study was to evaluate whether the combined treatment of growth hormone (GH) and gonadotropins can improve ovulation stimulation in previously poor responders. Twelve patients who, had suboptimal responses in previous in vitro fertilization cycle were enrolled. They underwent 1 cycle with gonadotropin-releasing hormone analogue (GnRH-a) and gonadotropins and another cycle with GnRH-a, gonadotropins, and GH. Serum gonadotropins, insulin-like growth factor-1 (IGF-1), and sex steroids, including estradiol (E 2 ), progesterone (P 4 ), testosterone, and androstenedione were measured on Day 2 and during ovulation induction. The serum IGF-1 level was higher in the GH cycle. There were no significant differences in the levels of the serum luteinizing hormone, E 2 , P 4 , testosterone, and androstenedione between the 2 cycles, so was IGF-1, E 2 and P 4 in follicular fluid. Co-treatment with GH did not improve the ovarian response. However, the GH cycles had better performance in terms of the number of oocytes fertilized and the pregnancy rate.
AB - The purpose of this study was to evaluate whether the combined treatment of growth hormone (GH) and gonadotropins can improve ovulation stimulation in previously poor responders. Twelve patients who, had suboptimal responses in previous in vitro fertilization cycle were enrolled. They underwent 1 cycle with gonadotropin-releasing hormone analogue (GnRH-a) and gonadotropins and another cycle with GnRH-a, gonadotropins, and GH. Serum gonadotropins, insulin-like growth factor-1 (IGF-1), and sex steroids, including estradiol (E 2 ), progesterone (P 4 ), testosterone, and androstenedione were measured on Day 2 and during ovulation induction. The serum IGF-1 level was higher in the GH cycle. There were no significant differences in the levels of the serum luteinizing hormone, E 2 , P 4 , testosterone, and androstenedione between the 2 cycles, so was IGF-1, E 2 and P 4 in follicular fluid. Co-treatment with GH did not improve the ovarian response. However, the GH cycles had better performance in terms of the number of oocytes fertilized and the pregnancy rate.
KW - Gonadotropin
KW - Human growth hormone
KW - In vitro fertilization
KW - Insulin-like growth factor-1
KW - Ovulation stimulation
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U2 - 10.1111/j.1447-0756.1996.tb01055.x
DO - 10.1111/j.1447-0756.1996.tb01055.x
M3 - Article
C2 - 8987326
AN - SCOPUS:0029830191
SN - 1341-8076
VL - 22
SP - 443
EP - 450
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
IS - 5
ER -