The use of transdermal fentanyl in cancer pain-A compliance study of outpatients in Taiwan

Tzeon Jye Chiou, Chun Yu Liu, Woan Fang Tzeng, Yu Chieh Su, Yih Chyang Weng, Chih Jen Hung, Yeh Tang, Yu Jen Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The aim of this study is to investigate cancer patients' response and side effects associated with transdermal therapeutic fentanyl (TTS-F), whose pain was hardly controlled by nonweak/weak opioids in Taiwan. From 2005 to 2006, 822 outpatients received TTS-F to collect pain assessment forms and diaries for 4 weeks. Most (78.7%) patients were initially prescribed 25 μg/h TTS-F. Doses were adjusted weekly at clinicians' discretion, according to pain assessment and side effects. Patients receiving 50 μg/h, 75 μg/h, and > 75 μg/h TTS-F had increased from 17.5% to 32.1%, 1.8% to 3.4%, and 1.9% to 2.2%, respectively, by week 2; further small increases were found in weeks 3 and 4. Pain palliation improved from 60.6% during week 1 to 78.6% at week 4. The common adverse effects were nausea/vomiting. Patient's compliance was >90%. This study found that the TTS-F is effective and well tolerated.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalAmerican Journal of Hospice and Palliative Medicine
Issue number1
Publication statusPublished - Feb 2010
Externally publishedYes


  • Cancer patients
  • Cohort study
  • Compliance
  • Opioids analgesics
  • Side effects
  • Transdermal fentanyl

ASJC Scopus subject areas

  • Medicine(all)


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