The ultrasensitive silver "protein" stain also detects nanograms of nucleic acids

Laura L. Somerville, Kuan Wang

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


The ultrasensitive silver staining procedure developed for proteins also stains nanogram quantities of RNA and DNA in polyacrylamide gels. A gradient polyacrylamide gel system is described which separates proteins from 104 to 106 Mr, RNA from 5S to 23S and DNA from 0.4 to 21 Kb. The sensitivity of nucleic acid silver staining in this gel system considerably exceeds that of commonly used DNA and RNA dye-binding stains.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Sept 16 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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