The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho; Hao Ching Wang; Tzu Ping Ko; Yuan Chih Chang; Andrew H J Wang

doi:10.1074/jbc.M114.590851

The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho, Hao Ching Wang, Tzu Ping Ko, Yuan Chih Chang, Andrew H J Wang

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.

Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.

Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.

Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.

Original language	English
Pages (from-to)	27046-27054
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	289
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M114.590851
Publication status	Published - Sept 26 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.590851

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abstract = "Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.",

author = "Ho, {Chun Han} and Wang, {Hao Ching} and Ko, {Tzu Ping} and Chang, {Yuan Chih} and Wang, {Andrew H J}",

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AU - Wang, Hao Ching

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AU - Chang, Yuan Chih

AU - Wang, Andrew H J

PY - 2014/9/26

Y1 - 2014/9/26

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The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Abstract

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3WX4 : CRYSTAL STRUCTURE of T4 PHAGE ARN PROTEIN

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The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Abstract

ASJC Scopus subject areas

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3WX4 : CRYSTAL STRUCTURE of T4 PHAGE ARN PROTEIN

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