Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.
Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.
Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.
Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.
|Number of pages||9|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - Sept 26 2014|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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3WX4 : CRYSTAL STRUCTURE of T4 PHAGE ARN PROTEIN
Ho, C. (Contributor), Wang, H. (Contributor), Ko, T. (Contributor) & Wang, A. H. (Contributor), RCSB-PDB, 2014
DOI: 10.2210/pdb3wx4/pdb, https://www.rcsb.org/structure/3WX4