THE SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS: Substituted at Residue Positions 27 and 31

James Blake; Liang‐Fu ‐F Tseng; Wen‐Chang ‐C Chang; Choh Hao Li

doi:10.1111/j.1399-3011.1978.tb02856.x

THE SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS: Substituted at Residue Positions 27 and 31

James Blake, Liang‐Fu ‐F Tseng, Wen‐Chang ‐C Chang, Choh Hao Li

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Four analogs of human β‐endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27‐phenylalanine, 31‐glycine]‐β_h‐endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.

Original language	English
Pages (from-to)	323-328
Number of pages	6
Journal	International Journal of Peptide and Protein Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-3011.1978.tb02856.x
Publication status	Published - Jan 1 1978
Externally published	Yes

Keywords

opiate activity
peptide synthesis
β‐endorphin

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1978.tb02856.x

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abstract = "Four analogs of human β‐endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27‐phenylalanine, 31‐glycine]‐βh‐endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.",

keywords = "opiate activity, peptide synthesis, β‐endorphin",

author = "James Blake and Tseng, {Liang‐Fu ‐F} and Chang, {Wen‐Chang ‐C} and Li, {Choh Hao}",

year = "1978",

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AU - Chang, Wen‐Chang ‐C

AU - Li, Choh Hao

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Four analogs of human β‐endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27‐phenylalanine, 31‐glycine]‐βh‐endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.

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KW - peptide synthesis

KW - β‐endorphin

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THE SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS: Substituted at Residue Positions 27 and 31

Abstract

Keywords

ASJC Scopus subject areas

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