The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats

Wun-Chang Ko; Joen Rong Sheu; Shu-Huey Tzeng; Chi Ming Chen

doi:10.1055/s-2006-957415

The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats

Wun-Chang Ko, Joen Rong Sheu, Shu-Huey Tzeng, Chi Ming Chen

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T- wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD₅₀, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	Planta Medica
Volume	64
Issue number	3
DOIs	https://doi.org/10.1055/s-2006-957415
Publication status	Published - 1998

Keywords

Antianginal effects
Butylidenephthalide
Ligusticum chuaxiong Hort.
Ligusticum wallichii Franch.
Myocardial ischemia
Pituitrin
T-wave lowering
Umbelliferae

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats",

abstract = "Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T- wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.",

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AU - Ko, Wun-Chang

AU - Sheu, Joen Rong

AU - Tzeng, Shu-Huey

AU - Chen, Chi Ming

PY - 1998

Y1 - 1998

N2 - Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T- wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.

AB - Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T- wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.

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KW - T-wave lowering

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The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats

Abstract

Keywords

ASJC Scopus subject areas

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