TY - JOUR
T1 - The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men
AU - Chen, Marcelo
AU - Huang, Yu Chuen
AU - Ko, I. ling
AU - Yang, Stone
AU - Chang, Yen Hwa
AU - Huang, William Ji Shian
AU - Chen, Yi Ming Arthur
N1 - Funding Information:
This study was supported by Mackay Memorial Hospital research grant MMH-HB-95-07.
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Objectives: To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations. Methods: This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined. Results: The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio = 1.49, 95% CI = 1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II (P = .028) and stages III+IV (P = .023), in patients of all Gleason scores (P < .05 in all subgroups), in patients with PSA levels >20 ng/mL (P = .001), and in patients with aggressive disease (P = .005). Conclusions: This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
AB - Objectives: To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations. Methods: This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined. Results: The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio = 1.49, 95% CI = 1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II (P = .028) and stages III+IV (P = .023), in patients of all Gleason scores (P < .05 in all subgroups), in patients with PSA levels >20 ng/mL (P = .001), and in patients with aggressive disease (P = .005). Conclusions: This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
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U2 - 10.1016/j.urology.2009.02.035
DO - 10.1016/j.urology.2009.02.035
M3 - Article
C2 - 19428064
AN - SCOPUS:69249220339
SN - 0090-4295
VL - 74
SP - 698
EP - 701
JO - Urology
JF - Urology
IS - 3
ER -
