The role of the septin family in spermiogenesis

Ying-Hung Lin; Yung-Che Kuo; Han-Sun Chiang; Pao-Lin Kuo

doi:10.4161/spmg.1.4.18326

The role of the septin family in spermiogenesis

Ying-Hung Lin, Yung-Che Kuo, Han-Sun Chiang, Pao-Lin Kuo

Department of Urology

Research output: Contribution to journal › Article › peer-review

Abstract

SEPTINS (FULL NAME: Septin; symbol name: SEPT) belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, including membrane compartmentalization, vesicle trafficking, mitosis and cytoskeletal remodeling. Two of the 14 family members in the mammalian species, Septin12 and 14 are expressed specifically in the testis. In the mouse, knockout of Septin4 and Septin12 leads to male sterility with distinctive sperm pathology (defective annulus or bent neck). In humans, sperm with abnormal expression patterns of SEPT4, 7 and 12 are more prevalent in infertile men. How septin filament is assembled/dissembled and how the SEPT-related complex regulates spermatogenesis still await further investigation.

Original language	English
Pages (from-to)	298-302
Number of pages	5
Journal	Spermatogenesis
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/spmg.1.4.18326
Publication status	Published - Oct 2011

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title = "The role of the septin family in spermiogenesis",

abstract = "SEPTINS (FULL NAME: Septin; symbol name: SEPT) belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, including membrane compartmentalization, vesicle trafficking, mitosis and cytoskeletal remodeling. Two of the 14 family members in the mammalian species, Septin12 and 14 are expressed specifically in the testis. In the mouse, knockout of Septin4 and Septin12 leads to male sterility with distinctive sperm pathology (defective annulus or bent neck). In humans, sperm with abnormal expression patterns of SEPT4, 7 and 12 are more prevalent in infertile men. How septin filament is assembled/dissembled and how the SEPT-related complex regulates spermatogenesis still await further investigation.",

author = "Ying-Hung Lin and Yung-Che Kuo and Han-Sun Chiang and Pao-Lin Kuo",

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doi = "10.4161/spmg.1.4.18326",

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AU - Chiang, Han-Sun

AU - Kuo, Pao-Lin

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Y1 - 2011/10

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AB - SEPTINS (FULL NAME: Septin; symbol name: SEPT) belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, including membrane compartmentalization, vesicle trafficking, mitosis and cytoskeletal remodeling. Two of the 14 family members in the mammalian species, Septin12 and 14 are expressed specifically in the testis. In the mouse, knockout of Septin4 and Septin12 leads to male sterility with distinctive sperm pathology (defective annulus or bent neck). In humans, sperm with abnormal expression patterns of SEPT4, 7 and 12 are more prevalent in infertile men. How septin filament is assembled/dissembled and how the SEPT-related complex regulates spermatogenesis still await further investigation.

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DO - 10.4161/spmg.1.4.18326

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JO - Spermatogenesis

JF - Spermatogenesis

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ER -

The role of the septin family in spermiogenesis

Abstract

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