Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.

Original languageEnglish
Title of host publicationChronic Inflammation: Causes, Treatment Options and Role in Disease
PublisherNova Science Publishers, Inc.
Number of pages18
ISBN (Print)9781628080940
Publication statusPublished - 2013

ASJC Scopus subject areas

  • General Medicine


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