The role of microparticles in inflammation and transfusion: A concise review

Fabrice Cognasse; Hind Hamzeh-Cognasse; Sandrine Laradi; Ming Li Chou; Jerard Seghatchian; Thierry Burnouf; Chantal Boulanger; Olivier Garraud; Nicolas Amabile

doi:10.1016/j.transci.2015.10.013

The role of microparticles in inflammation and transfusion: A concise review

Fabrice Cognasse
, Hind Hamzeh-Cognasse
, Sandrine Laradi
, Ming Li Chou
, Jerard Seghatchian
, Thierry Burnouf
, Chantal Boulanger
, Olivier Garraud
, Nicolas Amabile

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

Abstract

Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.

Original language	English
Pages (from-to)	159-167
Number of pages	9
Journal	Transfusion and Apheresis Science
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.transci.2015.10.013
Publication status	Published - Oct 1 2015

Keywords

Inflammation
MPs
Transfusion

ASJC Scopus subject areas

Hematology

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10.1016/j.transci.2015.10.013

Cite this

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abstract = "Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.",

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T2 - A concise review

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AU - Laradi, Sandrine

AU - Chou, Ming Li

AU - Seghatchian, Jerard

AU - Burnouf, Thierry

AU - Boulanger, Chantal

AU - Garraud, Olivier

AU - Amabile, Nicolas

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AB - Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.

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KW - MPs

KW - Transfusion

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DO - 10.1016/j.transci.2015.10.013

M3 - Review article

C2 - 26584596

AN - SCOPUS:84983155181

SN - 1473-0502

VL - 53

SP - 159

EP - 167

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

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ER -

The role of microparticles in inflammation and transfusion: A concise review

Abstract

Keywords

ASJC Scopus subject areas

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