TY - JOUR
T1 - The role of microparticles in inflammation and transfusion
T2 - A concise review
AU - Cognasse, Fabrice
AU - Hamzeh-Cognasse, Hind
AU - Laradi, Sandrine
AU - Chou, Ming Li
AU - Seghatchian, Jerard
AU - Burnouf, Thierry
AU - Boulanger, Chantal
AU - Garraud, Olivier
AU - Amabile, Nicolas
N1 - Publisher Copyright:
© 2015.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.
AB - Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.
KW - Inflammation
KW - MPs
KW - Transfusion
UR - http://www.scopus.com/inward/record.url?scp=84983155181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983155181&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2015.10.013
DO - 10.1016/j.transci.2015.10.013
M3 - Review article
C2 - 26584596
AN - SCOPUS:84983155181
SN - 1473-0502
VL - 53
SP - 159
EP - 167
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 2
ER -