The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Wen Wei Sung; Huei Lee

doi:10.4161/onci.25854

The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Wen Wei Sung
, Huei Lee

Ph.D. Program for Cancer Molecular Biology and Drug Discovery

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.

Original language	English
Article number	e25854
Journal	OncoImmunology
Volume	2
Issue number	9
DOIs	https://doi.org/10.4161/onci.25854
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CIP2A
HPV
IL-10
IL-10R
Lung cancer

ASJC Scopus subject areas

Oncology
Immunology and Allergy
Immunology

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10.4161/onci.25854

Cite this

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title = "The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma",

abstract = "The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.",

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AU - Lee, Huei

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N2 - The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.

AB - The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.

KW - CIP2A

KW - HPV

KW - IL-10

KW - IL-10R

KW - Lung cancer

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UR - https://www.scopus.com/pages/publications/84890285097#tab=citedBy

U2 - 10.4161/onci.25854

DO - 10.4161/onci.25854

M3 - Article

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VL - 2

JO - OncoImmunology

JF - OncoImmunology

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ER -

The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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