TY - JOUR
T1 - The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders
AU - Sharma, Ram
AU - Sharma, Sachin
AU - Thakur, Amandeep
AU - Singh, Arshdeep
AU - Singh, Jagjeet
AU - Nepali, Kunal
AU - Liou, Jing Ping
N1 - Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022/8
Y1 - 2022/8
N2 - Epigenetic mutations like aberrant DNA methylation, histone modifications, or RNA silencing are found in a number of human diseases. This review article discusses the epigenetic mechanisms involved in neurodegenerative disorders, cardiovascular disorders, auto-immune disorders and genomic imprinting disorders. In addition, emerging epigenetic therapeutic strategies for the treatment of such disorders are presented. Medicinal chemistry campaigns highlighting the efforts of the chem-ists invested towards the rational design of small molecule inhibitors have also been included. Pleas-ingly, several classes of epigenetic inhibitors, DNMT, HDAC, BET, HAT, and HMT inhibitors, along with RNA based therapies, have exhibited the potential to emerge as therapeutics in the longer run. It is quite hopeful that epigenetic modulator-based therapies will advance to clinical stage investigations by leaps and bounds.
AB - Epigenetic mutations like aberrant DNA methylation, histone modifications, or RNA silencing are found in a number of human diseases. This review article discusses the epigenetic mechanisms involved in neurodegenerative disorders, cardiovascular disorders, auto-immune disorders and genomic imprinting disorders. In addition, emerging epigenetic therapeutic strategies for the treatment of such disorders are presented. Medicinal chemistry campaigns highlighting the efforts of the chem-ists invested towards the rational design of small molecule inhibitors have also been included. Pleas-ingly, several classes of epigenetic inhibitors, DNMT, HDAC, BET, HAT, and HMT inhibitors, along with RNA based therapies, have exhibited the potential to emerge as therapeutics in the longer run. It is quite hopeful that epigenetic modulator-based therapies will advance to clinical stage investigations by leaps and bounds.
KW - auto-immune disorder
KW - cardiovascular disorders
KW - DNA methylation
KW - Epigenetics
KW - genomic imprinting disorders
KW - neurodegenerative disorders
UR - http://www.scopus.com/inward/record.url?scp=85137935800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137935800&partnerID=8YFLogxK
U2 - 10.2174/1389557522666220217103441
DO - 10.2174/1389557522666220217103441
M3 - Review article
C2 - 35176978
AN - SCOPUS:85137935800
SN - 1389-5575
VL - 22
SP - 1977
EP - 2011
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 15
ER -
