Abstract
Objective: To elucidate the role of mixed lymphocyte reaction blocking factors (BF) and complement-dependent antipaternal lymphocytotoxic antibodies on the outcome of pregnancy in unexplained recurrent spontaneous aborters. Design: A controlled study of immunotherapy in which the treated group was immunized with the husband's or a third party donor's lymphocytes and the control group received autologous lymphocytes. Setting: Tertiary care institution. Patients: Forty-three patients in the control group and 48 patients in the treated group. Intervention: The before and after immunization levels of BF and antipaternal lymphocytotoxic antibodies were measured. Main Outcome Measures: The existence or changing pattern of BF and antipaternal lymphocytotoxic antibodies levels before and after immunization had no influence on the pregnancy outcome in either group of patients. Conclusion: Neither BF nor antipaternal lymphocytotoxic antibodies is essential for successful pregnancy. They probably reflect the immunological response of the mother to exposure to fetal antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 691-696 |
| Number of pages | 6 |
| Journal | Fertility and Sterility |
| Volume | 58 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1992 |
| Externally published | Yes |
Keywords
- antipaternal lymphocytotoxic antibody
- blocking factor
- lymphocyte immunotherapy
- Recurrent spontaneous abortion
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology