The Role of Autophagy in Type 2 Diabetic Kidney Disease Management

Che Hao Tseng, Kavya M. Shah, I. Jen Chiu, Li Li Hsiao

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Diabetic kidney disease (DKD), or diabetic nephropathy (DN), is one of the most prevalent complications of type 2 diabetes mellitus (T2DM) and causes severe burden on the general welfare of T2DM patients around the world. While several new agents have shown promise in treating this condition and potentially halting the progression of the disease, more work is needed to understand the complex regulatory network involved in the disorder. Recent studies have provided new insights into the connection between autophagy, a physiological metabolic process known to maintain cellular homeostasis, and the pathophysiological pathways of DKD. Typically, autophagic activity plays a role in DKD progression mainly by promoting an inflammatory response to tissue damage, while both overactivated and downregulated autophagy worsen disease outcomes in different stages of DKD. This correlation demonstrates the potential of autophagy as a novel therapeutic target for the disease, and also highlights new possibilities for utilizing already available DN-related medications. In this review, we summarize findings on the relationship between autophagy and DKD, and the impact of these results on clinical management strategies.

Original languageEnglish
Article number2691
JournalCells
Volume12
Issue number23
DOIs
Publication statusPublished - Dec 2023

Keywords

  • autophagy
  • diabetic kidney disease
  • diabetic nephropathy

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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