The risk of cancer among patients with sleep disturbance: A nationwide retrospective study in Taiwan

Li Yu Hu; Pan Ming Chen; Yu Wen Hu; Cheng Che Shen; Chin Lin Perng; Tung Ping Su; Sang Hue Yen; Cheng Hwai Tzeng; Tzeon Jye Chiou; Chiu Mei Yeh; Tzeng Ji Chen; Wei Shu Wang; Chia Jen Liu

doi:10.1016/j.annepidem.2013.09.002

The risk of cancer among patients with sleep disturbance: A nationwide retrospective study in Taiwan

Li Yu Hu, Pan Ming Chen, Yu Wen Hu, Cheng Che Shen, Chin Lin Perng, Tung Ping Su, Sang Hue Yen, Cheng Hwai Tzeng, Tzeon Jye Chiou, Chiu Mei Yeh, Tzeng Ji Chen, Wei Shu Wang, Chia Jen Liu

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Purpose: To investigate the risk of cancer among patients with nonapnea sleep disorders (SDs). Methods: We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population. Results: During the 10-year study period, 2062 cancers developed among 63,381 SD patients, who were observed for 382,826 person-years (median follow-up of 6.23 years). The SIR for all cancers was 1.19 (95% confidence interval [CI], 1.14-1.24). For specific cancer types, SD patients exhibited an increased SIR for liver and lung cancers (1.44; 95% CI, 1.28-1.61 and 1.34; 95% CI, 1.18-1.51, respectively). Conclusions: We observed that overall cancer risk is increased among Asian SD patients. In terms of individual cancers, the risks of liver and lung cancers were elevated. Clinicians should be aware of the possibility of increased liver and lung cancers among SD patients in Taiwan. A prospective study is necessary to confirm these findings.

Original language	English
Pages (from-to)	757-761
Number of pages	5
Journal	Annals of Epidemiology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.annepidem.2013.09.002
Publication status	Published - Dec 2013
Externally published	Yes

Keywords

Dyssomnias
National Health Insurance Research Database (NHIRD)
Neoplasms
Risk
Standard incidence ratio (SIR)

ASJC Scopus subject areas

Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.annepidem.2013.09.002

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@article{f1d26047ea874900a7ef11706c76e20a,

title = "The risk of cancer among patients with sleep disturbance: A nationwide retrospective study in Taiwan",

abstract = "Purpose: To investigate the risk of cancer among patients with nonapnea sleep disorders (SDs). Methods: We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population. Results: During the 10-year study period, 2062 cancers developed among 63,381 SD patients, who were observed for 382,826 person-years (median follow-up of 6.23 years). The SIR for all cancers was 1.19 (95% confidence interval [CI], 1.14-1.24). For specific cancer types, SD patients exhibited an increased SIR for liver and lung cancers (1.44; 95% CI, 1.28-1.61 and 1.34; 95% CI, 1.18-1.51, respectively). Conclusions: We observed that overall cancer risk is increased among Asian SD patients. In terms of individual cancers, the risks of liver and lung cancers were elevated. Clinicians should be aware of the possibility of increased liver and lung cancers among SD patients in Taiwan. A prospective study is necessary to confirm these findings.",

keywords = "Dyssomnias, National Health Insurance Research Database (NHIRD), Neoplasms, Risk, Standard incidence ratio (SIR)",

author = "Hu, {Li Yu} and Chen, {Pan Ming} and Hu, {Yu Wen} and Shen, {Cheng Che} and Perng, {Chin Lin} and Su, {Tung Ping} and Yen, {Sang Hue} and Tzeng, {Cheng Hwai} and Chiou, {Tzeon Jye} and Yeh, {Chiu Mei} and Chen, {Tzeng Ji} and Wang, {Wei Shu} and Liu, {Chia Jen}",

note = "Funding Information: We wish to thank C.-M.Y. for her assistance with the statistical analyses and Huei-Sing Chang for technical support. This study was supported by grants from Taipei Veterans General Hospital ( V102D-001-1 and V102D-001-2 ) and Yuli Veterans Hospital ( VHYL-102-08 ).",

year = "2013",

month = dec,

doi = "10.1016/j.annepidem.2013.09.002",

language = "English",

volume = "23",

pages = "757--761",

journal = "Annals of Epidemiology",

issn = "1047-2797",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - The risk of cancer among patients with sleep disturbance

T2 - A nationwide retrospective study in Taiwan

AU - Hu, Li Yu

AU - Chen, Pan Ming

AU - Hu, Yu Wen

AU - Shen, Cheng Che

AU - Perng, Chin Lin

AU - Su, Tung Ping

AU - Yen, Sang Hue

AU - Tzeng, Cheng Hwai

AU - Chiou, Tzeon Jye

AU - Yeh, Chiu Mei

AU - Chen, Tzeng Ji

AU - Wang, Wei Shu

AU - Liu, Chia Jen

N1 - Funding Information: We wish to thank C.-M.Y. for her assistance with the statistical analyses and Huei-Sing Chang for technical support. This study was supported by grants from Taipei Veterans General Hospital ( V102D-001-1 and V102D-001-2 ) and Yuli Veterans Hospital ( VHYL-102-08 ).

PY - 2013/12

Y1 - 2013/12

N2 - Purpose: To investigate the risk of cancer among patients with nonapnea sleep disorders (SDs). Methods: We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population. Results: During the 10-year study period, 2062 cancers developed among 63,381 SD patients, who were observed for 382,826 person-years (median follow-up of 6.23 years). The SIR for all cancers was 1.19 (95% confidence interval [CI], 1.14-1.24). For specific cancer types, SD patients exhibited an increased SIR for liver and lung cancers (1.44; 95% CI, 1.28-1.61 and 1.34; 95% CI, 1.18-1.51, respectively). Conclusions: We observed that overall cancer risk is increased among Asian SD patients. In terms of individual cancers, the risks of liver and lung cancers were elevated. Clinicians should be aware of the possibility of increased liver and lung cancers among SD patients in Taiwan. A prospective study is necessary to confirm these findings.

AB - Purpose: To investigate the risk of cancer among patients with nonapnea sleep disorders (SDs). Methods: We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population. Results: During the 10-year study period, 2062 cancers developed among 63,381 SD patients, who were observed for 382,826 person-years (median follow-up of 6.23 years). The SIR for all cancers was 1.19 (95% confidence interval [CI], 1.14-1.24). For specific cancer types, SD patients exhibited an increased SIR for liver and lung cancers (1.44; 95% CI, 1.28-1.61 and 1.34; 95% CI, 1.18-1.51, respectively). Conclusions: We observed that overall cancer risk is increased among Asian SD patients. In terms of individual cancers, the risks of liver and lung cancers were elevated. Clinicians should be aware of the possibility of increased liver and lung cancers among SD patients in Taiwan. A prospective study is necessary to confirm these findings.

KW - Dyssomnias

KW - National Health Insurance Research Database (NHIRD)

KW - Neoplasms

KW - Risk

KW - Standard incidence ratio (SIR)

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U2 - 10.1016/j.annepidem.2013.09.002

DO - 10.1016/j.annepidem.2013.09.002

M3 - Article

C2 - 24404566

AN - SCOPUS:84888045939

SN - 1047-2797

VL - 23

SP - 757

EP - 761

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 12

ER -

The risk of cancer among patients with sleep disturbance: A nationwide retrospective study in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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