The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

Shih Yi Lin; Wei Ming Lin; Cheng Li Lin; Tse Yen Yang; Fung Chang Sung; Yuan Hung Wang; Chia Hung Kao

doi:10.1016/j.ejim.2014.01.001

The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

Shih Yi Lin
, Wei Ming Lin
, Cheng Li Lin
, Tse Yen Yang
, Fung Chang Sung
, Yuan Hung Wang
, Chia Hung Kao

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

Original language	English
Pages (from-to)	276-280
Number of pages	5
Journal	European Journal of Internal Medicine
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.ejim.2014.01.001
Publication status	Published - Mar 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

End-stage renal disease
Hyperparathyroidism
Thyroid cancer

ASJC Scopus subject areas

Internal Medicine

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10.1016/j.ejim.2014.01.001

Cite this

@article{90a257e66c5f4e4bafb49498006aa6f2,

title = "The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study",

abstract = "Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95\% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95\% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.",

keywords = "End-stage renal disease, Hyperparathyroidism, Thyroid cancer",

author = "Lin, \{Shih Yi\} and Lin, \{Wei Ming\} and Lin, \{Cheng Li\} and Yang, \{Tse Yen\} and Sung, \{Fung Chang\} and Wang, \{Yuan Hung\} and Kao, \{Chia Hung\}",

note = "Funding Information: The study was supported in part by the study projects (DMR-101-061 and DMR-100-076) in our hospital, the Taiwan Department of Health Clinical Trial Research Center for Excellence ( DOH102-TD-B-111-004 ), and the Taiwan Department of Health Cancer Research Center for Excellence ( DOH102-TD-C-111-005 ). The funders played no role in study design, data collection and analysis, decision to publish, or manuscript preparation. No additional external funding was received for this study.",

year = "2014",

month = mar,

doi = "10.1016/j.ejim.2014.01.001",

language = "English",

volume = "25",

pages = "276--280",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease

T2 - A population based cohort study

AU - Lin, Shih Yi

AU - Lin, Wei Ming

AU - Lin, Cheng Li

AU - Yang, Tse Yen

AU - Sung, Fung Chang

AU - Wang, Yuan Hung

AU - Kao, Chia Hung

N1 - Funding Information: The study was supported in part by the study projects (DMR-101-061 and DMR-100-076) in our hospital, the Taiwan Department of Health Clinical Trial Research Center for Excellence ( DOH102-TD-B-111-004 ), and the Taiwan Department of Health Cancer Research Center for Excellence ( DOH102-TD-C-111-005 ). The funders played no role in study design, data collection and analysis, decision to publish, or manuscript preparation. No additional external funding was received for this study.

PY - 2014/3

Y1 - 2014/3

N2 - Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

AB - Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

KW - End-stage renal disease

KW - Hyperparathyroidism

KW - Thyroid cancer

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The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

Abstract

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Keywords

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