The  Real- world  Experience  of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan

Chia-Yau Chang; C-H Tsai; J-R Tsai; Pei-Yi Lai; Y-L Liu; S.-H. Hu; Y.-C. Chen

The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan

Chia-Yau Chang, C-H Tsai , J-R Tsai, Pei-Yi Lai, Y-L Liu, S.-H. Hu, Y.-C. Chen

Research output: Contribution to journal › Special issue › peer-review

Abstract

Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed.

Original language	English
Article number	PB0289
Pages (from-to)	297
Number of pages	1
Journal	Research and Practice in Thrombosis and Haemostasis
Volume	3
Issue number	S1
Publication status	Published - Jun 2019

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The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan. / Chang, Chia-Yau; Tsai , C-H; Tsai, J-R et al.
In: Research and Practice in Thrombosis and Haemostasis, Vol. 3, No. S1, PB0289, 06.2019, p. 297.

Research output: Contribution to journal › Special issue › peer-review

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title = "The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan",

abstract = "Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed. ",

author = "Chia-Yau Chang and C-H Tsai and J-R Tsai and Pei-Yi Lai and Y-L Liu and S.-H. Hu and Y.-C. Chen",

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T1 - The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan

AU - Chang, Chia-Yau

AU - Tsai , C-H

AU - Tsai, J-R

AU - Lai, Pei-Yi

AU - Liu, Y-L

AU - Hu, S.-H.

AU - Chen, Y.-C.

PY - 2019/6

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N2 - Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed.

AB - Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed.

UR - https://doi.org/10.1002/rth2.12229

M3 - Special issue

SN - 2475-0379

VL - 3

SP - 297

JO - Research and Practice in Thrombosis and Haemostasis

JF - Research and Practice in Thrombosis and Haemostasis

IS - S1

M1 - PB0289

ER -

The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan

Abstract

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