TY - JOUR
T1 - The protective effect of curcumin on ischemia-reperfusion-induced liver injury
AU - Lin, C. M.
AU - Lee, J. F.
AU - Chiang, L. L.
AU - Chen, C. F.
AU - Wang, D.
AU - Su, Chien-Ling
N1 - Funding Information:
Supported by operating grants ( SKH-TMU-98-10 ). Shin Kong Wu-Ho-Su memorial hospital and Taipei medical university research grant.
PY - 2012/5
Y1 - 2012/5
N2 - Objective: Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods: Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results: The protocol resulted in elevation of blood NO (P
AB - Objective: Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods: Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results: The protocol resulted in elevation of blood NO (P
UR - http://www.scopus.com/inward/record.url?scp=84860775508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860775508&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2012.01.081
DO - 10.1016/j.transproceed.2012.01.081
M3 - Article
C2 - 22564600
AN - SCOPUS:84860775508
SN - 0041-1345
VL - 44
SP - 974
EP - 977
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 4
ER -