TY - JOUR
T1 - The prevalence of recurrent spontaneous abortions, cancer, and congenital anomalies in the families of couples with recurrent spontaneous abortions or gestational trophoblastic tumors
AU - Ho, Hong Nerng
AU - Gill, Thomas J.
AU - Hsieh, Chang Yao
AU - Yang, Yu Shih
AU - Lee, Tzu Yao
N1 - Funding Information:
From the Department of Obstetrics and Gynecology, National Taiwan University Hospital, and the Department of Pathology, University of Pittsburgh School of Medicine. Supported by grants from the National Science Council of the Republic of China (NSC-79-0412-B002-111 and 112), the Tim Camcio Memorial Cancer Fund, the Beaver County Cancer Society, and the Pathology Education and Research Foundation. Received for publication November 30, 1990; revised March 5, 1991; accepted March 22,1991. Reprint requests: Thomas]. Gill 111, MD, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - This study extends our previous work on the genetics of recurrent spontaneous abortion and of gestational trophoblastic tumors in an ethnically homogeneous population of Chinese in Taiwan by comparing the prevalence of recurrent spontaneous abortions, cancer, and congenital anomalies in the first-, second-, and third-degree relatives of the index couples to that of normally fertile couples from the same population. The rationale for this study was to provide another test for our hypothesis that genes linked to the major histocompatibility complex are responsible for the diseases in the index couples. If they are, these genes should segregate with a higher frequency in the relatives of the index couples than in the relatives of normally fertile couples and lead to a higher prevalence of these diseases in the extended families. Such a difference was found and adds support to our hypothesis that major histocompatibility complex-linked genes affect growth, development, and susceptibility to cancer.
AB - This study extends our previous work on the genetics of recurrent spontaneous abortion and of gestational trophoblastic tumors in an ethnically homogeneous population of Chinese in Taiwan by comparing the prevalence of recurrent spontaneous abortions, cancer, and congenital anomalies in the first-, second-, and third-degree relatives of the index couples to that of normally fertile couples from the same population. The rationale for this study was to provide another test for our hypothesis that genes linked to the major histocompatibility complex are responsible for the diseases in the index couples. If they are, these genes should segregate with a higher frequency in the relatives of the index couples than in the relatives of normally fertile couples and lead to a higher prevalence of these diseases in the extended families. Such a difference was found and adds support to our hypothesis that major histocompatibility complex-linked genes affect growth, development, and susceptibility to cancer.
KW - congenital anomalies
KW - genetics of cancer
KW - Genetics of reproduction
KW - human leukocyte antigen sharing
KW - recurrent spontaneous abortion
UR - http://www.scopus.com/inward/record.url?scp=0025738956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025738956&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(91)90117-A
DO - 10.1016/0002-9378(91)90117-A
M3 - Article
C2 - 1651649
AN - SCOPUS:0025738956
SN - 0002-9378
VL - 165
SP - 461
EP - 466
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -
