The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice

Satoshi Fujii; Andrew H.‐J Wang; Gary J. Quigley; Henk Westerink; Gijs Van Der Marel; Jacques H. Van Boom; Alexander Rich

doi:10.1002/bip.360240118

The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice

Satoshi Fujii, Andrew H.‐J Wang, Gary J. Quigley, Henk Westerink, Gijs Van Der Marel, Jacques H. Van Boom, Alexander Rich

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Both (dC‐dG)₄ and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.

Original language	English
Pages (from-to)	243-250
Number of pages	8
Journal	Biopolymers
Volume	24
Issue number	1
DOIs	https://doi.org/10.1002/bip.360240118
Publication status	Published - Jan 1985
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

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abstract = "Both (dC‐dG)4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.",

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AU - Fujii, Satoshi

AU - Wang, Andrew H.‐J

AU - Quigley, Gary J.

AU - Westerink, Henk

AU - Van Der Marel, Gijs

AU - Van Boom, Jacques H.

AU - Rich, Alexander

PY - 1985/1

Y1 - 1985/1

N2 - Both (dC‐dG)4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.

AB - Both (dC‐dG)4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.

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The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice

Abstract

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