The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Cheng Kuei Chang; Fu Yu Chueh; Ming Tsuen Hsieh; Mao Tsun Lin

doi:10.1016/S0304-3940(99)00322-5

The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Cheng Kuei Chang, Fu Yu Chueh, Ming Tsuen Hsieh, Mao Tsun Lin

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Neuroscience Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00322-5
Publication status	Published - May 28 1999
Externally published	Yes

Keywords

Brain
Cerebral ischemia
Heatstroke
Monoamines
Neuronal injury
Tetrahydroxypalmatine

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(99)00322-5

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title = "The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke",

abstract = "After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.",

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author = "Chang, {Cheng Kuei} and Chueh, {Fu Yu} and Hsieh, {Ming Tsuen} and Lin, {Mao Tsun}",

note = "Funding Information: This work was supported by the National Science Council (Taipei, Taiwan) Grant NSC87-2314-B-010-021 and the Ministry of Education grant NRICM–88108. ",

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AU - Chang, Cheng Kuei

AU - Chueh, Fu Yu

AU - Hsieh, Ming Tsuen

AU - Lin, Mao Tsun

N1 - Funding Information: This work was supported by the National Science Council (Taipei, Taiwan) Grant NSC87-2314-B-010-021 and the Ministry of Education grant NRICM–88108.

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N2 - After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

AB - After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

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KW - Cerebral ischemia

KW - Heatstroke

KW - Monoamines

KW - Neuronal injury

KW - Tetrahydroxypalmatine

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The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Abstract

Keywords

ASJC Scopus subject areas

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