TY - JOUR
T1 - The multifaceted role of mesenchymal stem cells in cancer
AU - Timaner, Michael
AU - Tsai, Kelvin K.
AU - Shaked, Yuval
N1 - Funding Information:
This review is supported by a grant from the European Research Council (no. 711222 ) given to YS. This work was supported in part by Ministry of Science and Technology, Taiwan (MOST 105-2314-B-400-018 to K.K.T.), Taipei Medical University ( DP2-107-21121-C-04 to K.K.T.), Wanfang Hospital , Chi-Mei Medical Center , and Hualien Tzu-Chi Hospital Joint Cancer Center Grant , Ministry of Health and Welfare, Taiwan ( MOHW108-TDU-B-212-124020 to K.K.T.)
Funding Information:
This review is supported by a grant from the European Research Council (no. 711222) given to YS. This work was supported in part by Ministry of Science and Technology, Taiwan (MOST 105-2314-B-400-018 to K.K.T.), Taipei Medical University (DP2-107-21121-C-04 to K.K.T.), Wanfang Hospital, Chi-Mei Medical Center, and Hualien Tzu-Chi Hospital Joint Cancer Center Grant, Ministry of Health and Welfare, Taiwan (MOHW108-TDU-B-212-124020 to K.K.T.)
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2
Y1 - 2020/2
N2 - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
AB - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
KW - Angiogenesis
KW - Immunosuppression
KW - Mesenchymal stem cells
KW - Metastasis
KW - Resistance
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U2 - 10.1016/j.semcancer.2019.06.003
DO - 10.1016/j.semcancer.2019.06.003
M3 - Review article
AN - SCOPUS:85067352621
SN - 1044-579X
VL - 60
SP - 225
EP - 237
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -
