The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner; Kelvin K. Tsai; Yuval Shaked

doi:10.1016/j.semcancer.2019.06.003

The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner, Kelvin K. Tsai, Yuval Shaked

Research output: Contribution to journal › Review article › peer-review

119 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

Original language	English
Pages (from-to)	225-237
Number of pages	13
Journal	Seminars in Cancer Biology
Volume	60
DOIs	https://doi.org/10.1016/j.semcancer.2019.06.003
Publication status	Published - Feb 2020

Keywords

Angiogenesis
Immunosuppression
Mesenchymal stem cells
Metastasis
Resistance

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2019.06.003

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title = "The multifaceted role of mesenchymal stem cells in cancer",

abstract = "Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.",

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author = "Michael Timaner and Tsai, {Kelvin K.} and Yuval Shaked",

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year = "2020",

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doi = "10.1016/j.semcancer.2019.06.003",

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volume = "60",

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AU - Timaner, Michael

AU - Tsai, Kelvin K.

AU - Shaked, Yuval

PY - 2020/2

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N2 - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

AB - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

KW - Angiogenesis

KW - Immunosuppression

KW - Mesenchymal stem cells

KW - Metastasis

KW - Resistance

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DO - 10.1016/j.semcancer.2019.06.003

M3 - Review article

AN - SCOPUS:85067352621

SN - 1044-579X

VL - 60

SP - 225

EP - 237

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

The multifaceted role of mesenchymal stem cells in cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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