TY - JOUR
T1 - The molecular structure of a DNA-triostin A complex
AU - Wang, Andrew H.J.
AU - Ughetto, Giovanni
AU - Quigley, Gary J.
AU - Hakoshima, Toshio
AU - Van Der Marel, Gijs A.
AU - Van Boom, Jacques H.
AU - Rich, Alexander
PY - 1984
Y1 - 1984
N2 - The molecular structure of triostin A, a cyclic octadepsipeptide antibiotic, has been solved complexed to a DNA double helical fragment with the sequence CGTACG (C, cytosine; G, guanine; T, thymine; A, adenine). The two planar quinoxaline rings of triostin A bis intercalate on the minor groove of the DNA double helix surrounding the CG base pairs at either end. The alanine residues form hydrogen bonds to the guanines. Base stacking in the DNA is perturbed, and the major binding interaction involves a large number of van der Waals contacts between the peptides and the nucleic acid. The adenine residues in the center are in the syn conformation and are paired to thymine through Hoogsteen base pairing.
AB - The molecular structure of triostin A, a cyclic octadepsipeptide antibiotic, has been solved complexed to a DNA double helical fragment with the sequence CGTACG (C, cytosine; G, guanine; T, thymine; A, adenine). The two planar quinoxaline rings of triostin A bis intercalate on the minor groove of the DNA double helix surrounding the CG base pairs at either end. The alanine residues form hydrogen bonds to the guanines. Base stacking in the DNA is perturbed, and the major binding interaction involves a large number of van der Waals contacts between the peptides and the nucleic acid. The adenine residues in the center are in the syn conformation and are paired to thymine through Hoogsteen base pairing.
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U2 - 10.1126/science.6474168
DO - 10.1126/science.6474168
M3 - Article
C2 - 6474168
AN - SCOPUS:0021217519
SN - 0036-8075
VL - 225
SP - 1115
EP - 1121
JO - Science
JF - Science
IS - 4667
ER -