The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis

Huey En Tzeng; Syuan Ling Lin; Louis Anoop Thadevoos; Chih Yuan Ko; Ju Fang Liu; Yu Wen Huang; Chih Yang Lin; Yi Chin Fong; Chih Hsin Tang

doi:10.3390/cancers13133347

The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis

Huey En Tzeng, Syuan Ling Lin, Louis Anoop Thadevoos, Chih Yuan Ko, Ju Fang Liu, Yu Wen Huang, Chih Yang Lin, Yi Chin Fong, Chih Hsin Tang

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.

Original language	English
Article number	3347
Journal	Cancers
Volume	13
Issue number	13
DOIs	https://doi.org/10.3390/cancers13133347
Publication status	Published - Jul 1 2021

Keywords

Chondrosarcoma
Metastasis
MiR-423-5p
MMP-2
NGF

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13133347

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title = "The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis",

abstract = "A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.",

keywords = "Chondrosarcoma, Metastasis, MiR-423-5p, MMP-2, NGF",

author = "Tzeng, {Huey En} and Lin, {Syuan Ling} and Thadevoos, {Louis Anoop} and Ko, {Chih Yuan} and Liu, {Ju Fang} and Huang, {Yu Wen} and Lin, {Chih Yang} and Fong, {Yi Chin} and Tang, {Chih Hsin}",

note = "Funding Information: Funding: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Bei-gang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Funding Information: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Beigang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/cancers13133347",

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AU - Tzeng, Huey En

AU - Lin, Syuan Ling

AU - Thadevoos, Louis Anoop

AU - Ko, Chih Yuan

AU - Liu, Ju Fang

AU - Huang, Yu Wen

AU - Lin, Chih Yang

AU - Fong, Yi Chin

AU - Tang, Chih Hsin

N1 - Funding Information: Funding: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Bei-gang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Funding Information: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Beigang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.

AB - A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.

KW - Chondrosarcoma

KW - Metastasis

KW - MiR-423-5p

KW - MMP-2

KW - NGF

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DO - 10.3390/cancers13133347

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VL - 13

JO - Cancers

JF - Cancers

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M1 - 3347

ER -

The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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