The Many Faces of Superficial Basal Cell Carcinoma -Clinicopathological and Immunohistochemical Studies of Three Different Lesions-

Kuo-Hsien Wang, Chia-Lang Fang, Chien-Chung Lai, Woan-Ruoh Lee

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Superficial basal cell carcinoma is a distinct variant of basal cell carcinoma not only histological- ly but also biologically. Its indolent growth and occasionally misleading clinical presentation can sometimes pose a diagnostic challenge to clinicians. In this report, we describe three lesions of super-ficial basal cell carcinoma in two Taiwanese patients.Their clinical appearances were drastically dif-ferent from each other. The histopathology of the three lesions varied in the aspects of the tumor islands and the components of peritumoral stroma. The diverse clinicopathological pictures of superfi-cial BCC demonstrate the complex and conditioned pathogenesis of the tumor. In addition, immuno-histochemical studies with Ki-67 and bc1-2were performed on our cases and two cases of trichoep-ithelioma as well. Ki-67 is epressed in a random fashion within the tumor nests of superficial BCC, while trichoepithelioma is barely positive with Ki-67. Diffuse staining of bc1-2 is seen on the tumor nests of superficial BCC. In contrast, only the periphery of the tumor nests is bc1-2 positive in tri-choepithelioma. The differential immunostaining profile of the two lesions reflects their respective biological behaviors and may be of value in separating the two conditions in certain problematic cases.
Translated title of the contribution表淺型基底細胞癌的多樣面貌-三不同病灶之臨床病理及免疫組織化學研究-
Original languageEnglish
Pages (from-to)335-343
Number of pages9
JournalDermatologica Sinica
Issue number4
Publication statusPublished - 2002


  • Superficial basal cell carcinoma
  • Histopathology
  • Ki-67
  • bc1-2


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