The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

C. C. Wu; Y. H. Wang; Y. M. Hsueh

doi:10.1201/b20466-170

The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

Original language	English
Title of host publication	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
Editors	Prosun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
Publisher	CRC Press/Balkema
Pages	359-360
Number of pages	2
ISBN (Print)	9781138029415
DOIs	https://doi.org/10.1201/b20466-170
Publication status	Published - 2016
Event	6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden Duration: Jun 19 2016 → Jun 23 2016

Publication series

Name	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference	6th International Congress on Arsenic in the Environment, AS 2016
Country/Territory	Sweden
City	Stockholm
Period	6/19/16 → 6/23/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pollution
Environmental Chemistry

Access to Document

10.1201/b20466-170

Cite this

Wu, C. C., Wang, Y. H., & Hsueh, Y. M. (2016). The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. In P. Bhattacharya, G. Jacks, J. Bundschuh, P. Bhattacharya, M. Vahter, J. Jarsjo, J. Jarsjo, J. Kumpiene, A. Ahmad, C. Sparrenbom, M. E. Donselaar, J. Bundschuh, R. Naidu, & R. Naidu (Eds.), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (pp. 359-360). (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). CRC Press/Balkema. https://doi.org/10.1201/b20466-170

The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. / Wu, C. C.; Wang, Y. H.; Hsueh, Y. M.
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. ed. / Prosun Bhattacharya; Gunnar Jacks; Jochen Bundschuh; Prosun Bhattacharya; Marie Vahter; Jerker Jarsjo; Jerker Jarsjo; Jurate Kumpiene; Arslan Ahmad; Charlotte Sparrenbom; Marinus Eric Donselaar; Jochen Bundschuh; Ravi Naidu; Ravi Naidu. CRC Press/Balkema, 2016. p. 359-360 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, CC , Wang, YH & Hsueh, YM 2016, The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. in P Bhattacharya, G Jacks, J Bundschuh, P Bhattacharya, M Vahter, J Jarsjo, J Jarsjo, J Kumpiene, A Ahmad, C Sparrenbom, ME Donselaar, J Bundschuh, R Naidu & R Naidu (eds), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016, CRC Press/Balkema, pp. 359-360, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, Sweden, 6/19/16. https://doi.org/10.1201/b20466-170

Wu CC , Wang YH , Hsueh YM. The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. In Bhattacharya P, Jacks G, Bundschuh J, Bhattacharya P, Vahter M, Jarsjo J, Jarsjo J, Kumpiene J, Ahmad A, Sparrenbom C, Donselaar ME, Bundschuh J, Naidu R, Naidu R, editors, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 359-360. (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). doi: 10.1201/b20466-170

Wu, C. C. ; Wang, Y. H. ; Hsueh, Y. M. / The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. editor / Prosun Bhattacharya ; Gunnar Jacks ; Jochen Bundschuh ; Prosun Bhattacharya ; Marie Vahter ; Jerker Jarsjo ; Jerker Jarsjo ; Jurate Kumpiene ; Arslan Ahmad ; Charlotte Sparrenbom ; Marinus Eric Donselaar ; Jochen Bundschuh ; Ravi Naidu ; Ravi Naidu. CRC Press/Balkema, 2016. pp. 359-360 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

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title = "The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk",

abstract = "The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95\% CI = 2.26{\textendash}11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95\% CI = 6.48{\textendash}26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.",

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N2 - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

AB - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

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The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

Abstract

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UN SDGs

ASJC Scopus subject areas

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