The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

C. C. Wu; Y. H. Wang; Y. M. Hsueh

doi:10.1201/b20466-170

The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

Original language	English
Title of host publication	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
Editors	Prosun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
Publisher	CRC Press/Balkema
Pages	359-360
Number of pages	2
ISBN (Print)	9781138029415
DOIs	https://doi.org/10.1201/b20466-170
Publication status	Published - 2016
Event	6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden Duration: Jun 19 2016 → Jun 23 2016

Publication series

Name	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference	6th International Congress on Arsenic in the Environment, AS 2016
Country/Territory	Sweden
City	Stockholm
Period	6/19/16 → 6/23/16

ASJC Scopus subject areas

Pollution
Environmental Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1201/b20466-170

Cite this

Wu, C. C., Wang, Y. H., & Hsueh, Y. M. (2016). The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. In P. Bhattacharya, G. Jacks, J. Bundschuh, P. Bhattacharya, M. Vahter, J. Jarsjo, J. Jarsjo, J. Kumpiene, A. Ahmad, C. Sparrenbom, M. E. Donselaar, J. Bundschuh, R. Naidu, & R. Naidu (Eds.), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (pp. 359-360). (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). CRC Press/Balkema. https://doi.org/10.1201/b20466-170

The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. / Wu, C. C.; Wang, Y. H.; Hsueh, Y. M.
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. ed. / Prosun Bhattacharya; Gunnar Jacks; Jochen Bundschuh; Prosun Bhattacharya; Marie Vahter; Jerker Jarsjo; Jerker Jarsjo; Jurate Kumpiene; Arslan Ahmad; Charlotte Sparrenbom; Marinus Eric Donselaar; Jochen Bundschuh; Ravi Naidu; Ravi Naidu. CRC Press/Balkema, 2016. p. 359-360 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, CC , Wang, YH & Hsueh, YM 2016, The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. in P Bhattacharya, G Jacks, J Bundschuh, P Bhattacharya, M Vahter, J Jarsjo, J Jarsjo, J Kumpiene, A Ahmad, C Sparrenbom, ME Donselaar, J Bundschuh, R Naidu & R Naidu (eds), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016, CRC Press/Balkema, pp. 359-360, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, Sweden, 6/19/16. https://doi.org/10.1201/b20466-170

Wu CC , Wang YH, Hsueh YM. The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. In Bhattacharya P, Jacks G, Bundschuh J, Bhattacharya P, Vahter M, Jarsjo J, Jarsjo J, Kumpiene J, Ahmad A, Sparrenbom C, Donselaar ME, Bundschuh J, Naidu R, Naidu R, editors, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 359-360. (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). doi: 10.1201/b20466-170

Wu, C. C. ; Wang, Y. H. ; Hsueh, Y. M. / The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. editor / Prosun Bhattacharya ; Gunnar Jacks ; Jochen Bundschuh ; Prosun Bhattacharya ; Marie Vahter ; Jerker Jarsjo ; Jerker Jarsjo ; Jurate Kumpiene ; Arslan Ahmad ; Charlotte Sparrenbom ; Marinus Eric Donselaar ; Jochen Bundschuh ; Ravi Naidu ; Ravi Naidu. CRC Press/Balkema, 2016. pp. 359-360 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

@inproceedings{ec30132dfeef4faf9bcbe06f970c7286,

title = "The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk",

abstract = "The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.",

author = "Wu, {C. C.} and Wang, {Y. H.} and Hsueh, {Y. M.}",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor & Francis Group, London.; 6th International Congress on Arsenic in the Environment, AS 2016 ; Conference date: 19-06-2016 Through 23-06-2016",

year = "2016",

doi = "10.1201/b20466-170",

language = "English",

isbn = "9781138029415",

series = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

publisher = "CRC Press/Balkema",

pages = "359--360",

editor = "Prosun Bhattacharya and Gunnar Jacks and Jochen Bundschuh and Prosun Bhattacharya and Marie Vahter and Jerker Jarsjo and Jerker Jarsjo and Jurate Kumpiene and Arslan Ahmad and Charlotte Sparrenbom and Donselaar, {Marinus Eric} and Jochen Bundschuh and Ravi Naidu and Ravi Naidu",

booktitle = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

}

TY - GEN

T1 - The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

AU - Wu, C. C.

AU - Wang, Y. H.

AU - Hsueh, Y. M.

PY - 2016

Y1 - 2016

N2 - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

AB - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

UR - http://www.scopus.com/inward/record.url?scp=85017010147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017010147&partnerID=8YFLogxK

U2 - 10.1201/b20466-170

DO - 10.1201/b20466-170

M3 - Conference contribution

AN - SCOPUS:85017010147

SN - 9781138029415

T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

SP - 359

EP - 360

BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

A2 - Bhattacharya, Prosun

A2 - Jacks, Gunnar

A2 - Bundschuh, Jochen

A2 - Bhattacharya, Prosun

A2 - Vahter, Marie

A2 - Jarsjo, Jerker

A2 - Kumpiene, Jurate

A2 - Ahmad, Arslan

A2 - Sparrenbom, Charlotte

A2 - Donselaar, Marinus Eric

A2 - Bundschuh, Jochen

A2 - Naidu, Ravi

PB - CRC Press/Balkema

T2 - 6th International Congress on Arsenic in the Environment, AS 2016

Y2 - 19 June 2016 through 23 June 2016

ER -

The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

Abstract

Publication series

Conference

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this