TY - GEN
T1 - The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk
AU - Wu, C. C.
AU - Wang, Y. H.
AU - Hsueh, Y. M.
N1 - Funding Information:
This study was supported by grants from National Science Council (NSC-97-2314-B-038-015-MY3 (1-3), NSC-97-2314-B-038-015-MY3 (2-3), NSC- 97-2314-B-038-015-MY3 (3-3)), NSC 100-2314-B- 038-026, MOST 104-2314-B-038-079 and MOST 104-2314-B-038-024.
Publisher Copyright:
© 2016 Taylor & Francis Group, London.
PY - 2016
Y1 - 2016
N2 - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.
AB - The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.
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U2 - 10.1201/b20466-170
DO - 10.1201/b20466-170
M3 - Conference contribution
AN - SCOPUS:85017010147
SN - 9781138029415
T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
SP - 359
EP - 360
BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
A2 - Bhattacharya, Prosun
A2 - Jacks, Gunnar
A2 - Bundschuh, Jochen
A2 - Bhattacharya, Prosun
A2 - Vahter, Marie
A2 - Jarsjo, Jerker
A2 - Jarsjo, Jerker
A2 - Kumpiene, Jurate
A2 - Ahmad, Arslan
A2 - Sparrenbom, Charlotte
A2 - Donselaar, Marinus Eric
A2 - Bundschuh, Jochen
A2 - Naidu, Ravi
A2 - Naidu, Ravi
PB - CRC Press/Balkema
T2 - 6th International Congress on Arsenic in the Environment, AS 2016
Y2 - 19 June 2016 through 23 June 2016
ER -
