TY - JOUR
T1 - The intracranial volume pressure response in increased intracranial pressure patients
T2 - Part 1. Calculation of the volume pressure indicator
AU - Lai, Hung Yi
AU - Lee, Ching Yi
AU - Hsu, Hsun Hui
AU - Lee, Shih Tseng
N1 - Funding Information:
The authors would like to thank Professor David J. Fairholm (Professor, Department of Neurosurgery, University of British Columbia ) for his advice and comments and Miss She-Hung Chan for her statistical assistance. The study was supported by the Chang Gung Medical Research Council (grant no. CMRPG 371581). No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or any organization with which the authors are associated.
PY - 2012/12
Y1 - 2012/12
N2 - Background The intracranial pressure (ICP) is usually continuously monitored in the management of patients with increased ICP. The aim of this study was to discover a mathematic equation to express the intracranial pressure- volume (P-V) curve and a single indicator to reflect the status of the curve. Methods Patients with severe brain damage who had bilateral external ventricular drainage (EVD) from December 2008 to February 2010 were included in this study. The EVD was used as drainage of CSF and ICP monitor. The successive volume pressure response [6] values were obtained by successive drainage of CSF from ICP 20-25 to 10 mmHg. Parabolic, exponential, and linear regression models were designed to have a single parameter as the indicator to determine the P-V curves. Results The mean of parameter "a" in the exponential equation is 1.473±0.054; in the parabolic equation, it is 0.332±0.061; and in the linear equation, it is 1.717±0.209. All regression equations of P-V curves had statistical significance (p
AB - Background The intracranial pressure (ICP) is usually continuously monitored in the management of patients with increased ICP. The aim of this study was to discover a mathematic equation to express the intracranial pressure- volume (P-V) curve and a single indicator to reflect the status of the curve. Methods Patients with severe brain damage who had bilateral external ventricular drainage (EVD) from December 2008 to February 2010 were included in this study. The EVD was used as drainage of CSF and ICP monitor. The successive volume pressure response [6] values were obtained by successive drainage of CSF from ICP 20-25 to 10 mmHg. Parabolic, exponential, and linear regression models were designed to have a single parameter as the indicator to determine the P-V curves. Results The mean of parameter "a" in the exponential equation is 1.473±0.054; in the parabolic equation, it is 0.332±0.061; and in the linear equation, it is 1.717±0.209. All regression equations of P-V curves had statistical significance (p
KW - Intracranial pressure
KW - Mathematical model
KW - Pressure-volume curve
KW - Pressure-volume relationship
KW - Volume pressure response
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U2 - 10.1007/s00701-010-0765-8
DO - 10.1007/s00701-010-0765-8
M3 - Article
C2 - 20714759
AN - SCOPUS:84871091669
SN - 0001-6268
VL - 154
SP - 2271
EP - 2275
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 12
ER -