The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

Wei Ting Lee; Jenn Ren Hsiao; Chun Yen Ou; Cheng Chih Huang; Chan Chi Chang; Sen Tien Tsai; Ken Chung Chen; Jehn Shyun Huang; Tung Yiu Wong; Yu Hsuan Lai; Yuan Hua Wu; Wei Ting Hsueh; Shang Yin Wu; Chia Jui Yen; Jang Yang Chang; Chen Lin Lin; Ya Ling Weng; Han Chien Yang; Yu Shan Chen; Jeffrey S. Chang

doi:10.1158/1055-9965.EPI-18-0425

The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

Wei Ting Lee, Jenn Ren Hsiao, Chun Yen Ou, Cheng Chih Huang, Chan Chi Chang, Sen Tien Tsai, Ken Chung Chen, Jehn Shyun Huang, Tung Yiu Wong, Yu Hsuan Lai, Yuan Hua Wu, Wei Ting Hsueh, Shang Yin Wu, Chia Jui Yen, Jang Yang Chang, Chen Lin Lin, Ya Ling Weng, Han Chien Yang, Yu Shan Chen, Jeffrey S. Chang

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

Original language	English
Pages (from-to)	248-257
Number of pages	10
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	28
Issue number	2
DOIs	https://doi.org/10.1158/1055-9965.EPI-18-0425
Publication status	Published - Feb 2019
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1055-9965.EPI-18-0425

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Lee, W. T., Hsiao, J. R., Ou, C. Y., Huang, C. C., Chang, C. C., Tsai, S. T., Chen, K. C., Huang, J. S., Wong, T. Y., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Wu, S. Y., Yen, C. J., Chang, J. Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S., & Chang, J. S. (2019). The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients. Cancer Epidemiology Biomarkers and Prevention, 28(2), 248-257. https://doi.org/10.1158/1055-9965.EPI-18-0425

Lee, WT, Hsiao, JR, Ou, CY, Huang, CC, Chang, CC, Tsai, ST, Chen, KC, Huang, JS, Wong, TY, Lai, YH, Wu, YH, Hsueh, WT, Wu, SY, Yen, CJ, Chang, JY, Lin, CL, Weng, YL, Yang, HC, Chen, YS & Chang, JS 2019, 'The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients', Cancer Epidemiology Biomarkers and Prevention, vol. 28, no. 2, pp. 248-257. https://doi.org/10.1158/1055-9965.EPI-18-0425

@article{b4e1ccb538c34351ac52f9ef3c58c4f8,

title = "The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients",

abstract = "Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.",

author = "Lee, {Wei Ting} and Hsiao, {Jenn Ren} and Ou, {Chun Yen} and Huang, {Cheng Chih} and Chang, {Chan Chi} and Tsai, {Sen Tien} and Chen, {Ken Chung} and Huang, {Jehn Shyun} and Wong, {Tung Yiu} and Lai, {Yu Hsuan} and Wu, {Yuan Hua} and Hsueh, {Wei Ting} and Wu, {Shang Yin} and Yen, {Chia Jui} and Chang, {Jang Yang} and Lin, {Chen Lin} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",

note = "Funding Information: This work was supported by grants from the Ministry of Science and Technology, Taiwan (106-2314-B-400-007 and 107-2314-B-400-003 to J.S. Chang, and 107-2314-B-006-041-MY3 to J.-R. Hsiao), the National Health Research Institutes, Taiwan (CA-107-SP-01 to J.S. Chang), and Next Generation Pathway of Taiwan Cancer Precision Medicine Program (TCPMP; MP10604-0007 to J.-Y. Chang). Publisher Copyright: {\textcopyright} 2018 American Association for Cancer Research.",

year = "2019",

month = feb,

doi = "10.1158/1055-9965.EPI-18-0425",

language = "English",

volume = "28",

pages = "248--257",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "2",

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TY - JOUR

T1 - The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

AU - Lee, Wei Ting

AU - Hsiao, Jenn Ren

AU - Ou, Chun Yen

AU - Huang, Cheng Chih

AU - Chang, Chan Chi

AU - Tsai, Sen Tien

AU - Chen, Ken Chung

AU - Huang, Jehn Shyun

AU - Wong, Tung Yiu

AU - Lai, Yu Hsuan

AU - Wu, Yuan Hua

AU - Hsueh, Wei Ting

AU - Wu, Shang Yin

AU - Yen, Chia Jui

AU - Chang, Jang Yang

AU - Lin, Chen Lin

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

N1 - Funding Information: This work was supported by grants from the Ministry of Science and Technology, Taiwan (106-2314-B-400-007 and 107-2314-B-400-003 to J.S. Chang, and 107-2314-B-006-041-MY3 to J.-R. Hsiao), the National Health Research Institutes, Taiwan (CA-107-SP-01 to J.S. Chang), and Next Generation Pathway of Taiwan Cancer Precision Medicine Program (TCPMP; MP10604-0007 to J.-Y. Chang). Publisher Copyright: © 2018 American Association for Cancer Research.

PY - 2019/2

Y1 - 2019/2

N2 - Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

AB - Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

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The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

Abstract

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UN SDGs

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