The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng; Hong Jen Liang; Ming Chung Deng; Kuo Ming Lee; Ryh Nan Pan; Jen Chang Yang; Yi You Huang; Der Zen Liu

doi:10.1016/j.tvjl.2009.05.019

The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng, Hong Jen Liang, Ming Chung Deng, Kuo Ming Lee, Ryh Nan Pan, Jen Chang Yang, Yi You Huang, Der Zen Liu

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

Original language	English
Pages (from-to)	204-210
Number of pages	7
Journal	Veterinary Journal
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.tvjl.2009.05.019
Publication status	Published - Aug 2010

Keywords

Adjuvant
Intranasal
Liposome
Newcastle disease virus
S-IgA

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tvjl.2009.05.019

Cite this

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title = "The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease",

abstract = "The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P",

keywords = "Adjuvant, Intranasal, Liposome, Newcastle disease virus, S-IgA",

author = "Tseng, {Li Ping} and Liang, {Hong Jen} and Deng, {Ming Chung} and Lee, {Kuo Ming} and Pan, {Ryh Nan} and Yang, {Jen Chang} and Huang, {Yi You} and Liu, {Der Zen}",

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AU - Tseng, Li Ping

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AU - Deng, Ming Chung

AU - Lee, Kuo Ming

AU - Pan, Ryh Nan

AU - Yang, Jen Chang

AU - Huang, Yi You

AU - Liu, Der Zen

PY - 2010/8

Y1 - 2010/8

N2 - The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

AB - The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

KW - Adjuvant

KW - Intranasal

KW - Liposome

KW - Newcastle disease virus

KW - S-IgA

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The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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