The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Chiang-Wen Lee; Thi Thuy Tien Vo; Ching-Zong Wu; Miao-Ching Chi; Chieh-Mo Lin; Mei-Ling Fang; I-Ta Lee

doi:10.3390/cancers12092505

The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Chiang-Wen Lee, Thi Thuy Tien Vo, Ching-Zong Wu, Miao-Ching Chi, Chieh-Mo Lin, Mei-Ling Fang, I-Ta Lee

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.

Original language	English
Article number	2505
Pages (from-to)	1-21
Number of pages	21
Journal	Cancers
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/cancers12092505
Publication status	Published - Sept 3 2020

Keywords

Antioxidant
Cancer
Carbon monoxide releasing molecules
Oxidative stress
Particulate matter
Redox signaling pathways

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers12092505

https://www.mdpi.com/2072-6694/12/9/2505

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title = "The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception",

abstract = "Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.",

keywords = "Antioxidant, Cancer, Carbon monoxide releasing molecules, Oxidative stress, Particulate matter, Redox signaling pathways",

author = "Chiang-Wen Lee and Vo, {Thi Thuy Tien} and Ching-Zong Wu and Miao-Ching Chi and Chieh-Mo Lin and Mei-Ling Fang and I-Ta Lee",

note = "Funding Information: Funding: This work was supported by the Taipei Medical University, grant number TMU108-AE1-B10; the Taipei Medical University Hospital, grant number 109TMU-TMUH-16; the Chang Gung University of Science Foundation, grant number ZRRPF6K0011-CWL; the Chang Gung Medical Research Program Foundation, grant number CMRPF6J0051 and CMRPF6H0101. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = sep,

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doi = "10.3390/cancers12092505",

language = "English",

volume = "12",

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AU - Wu, Ching-Zong

AU - Chi, Miao-Ching

AU - Lin, Chieh-Mo

AU - Fang, Mei-Ling

AU - Lee, I-Ta

N1 - Funding Information: Funding: This work was supported by the Taipei Medical University, grant number TMU108-AE1-B10; the Taipei Medical University Hospital, grant number 109TMU-TMUH-16; the Chang Gung University of Science Foundation, grant number ZRRPF6K0011-CWL; the Chang Gung Medical Research Program Foundation, grant number CMRPF6J0051 and CMRPF6H0101. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9/3

Y1 - 2020/9/3

N2 - Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.

AB - Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.

KW - Antioxidant

KW - Cancer

KW - Carbon monoxide releasing molecules

KW - Oxidative stress

KW - Particulate matter

KW - Redox signaling pathways

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The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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