The impacts of in-hospital invasive strategy on long-term outcome in elderly patients with non-ST-elevation myocardial infarction

Shao Sung Huang, Hsin Bnag Leu, Tse Min Lu, Tao Cheng Wu, Ying Hwa Chen, Jaw Wen Chen, Shing Jong Lin, Wan Leong Chan

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: The benefit of utilizing an invasive strategy in elderly Chinese patients with non-ST-elevation myocardial infarction (NSTEMI) remains unclear. The aim of this study was to determine whether in-hospital revascularization is associated with long-term prognosis in elderly Chinese patients with NSTEMI, as compared with younger patients. Methods: All patients were followed up for at least 3 years or until the occurrence of a major event. The primary endpoint was all-cause mortality, and the secondary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including death, nonfatal MI, and ischemic stroke. Results: A total of 343 consecutive NSTEMI patients (148 over the age of 75 years and 195 aged < 75 years) were enrolled. Coronary angiography was performed less frequently in elderly patients (66% vs. 76%; p = 0.027). Multiple logistic regression analysis confirmed the benefit of in-hospital revascularization in the elderly and younger patients, with a statistically significant reduction in the odds of all-cause death and MACE at 1 year and 3 years, respectively. In a multivariable Cox regression analysis, in-hospital revascularization was an independent predictor of future MACE not only in elderly patients [hazard ratio (HR), 0.61; 95% confidence interval (CI), 0.38-0.97] but also in younger patients as well (HR, 0.51; 95% CI, 0.31-0.84). Conclusions: In Chinese patients with NSTEMI, in-hospital revascularization was associated with significant benefits at 1 year and 3 years in both younger and elderly groups. These results are consistent with the published literature and suggest that advanced age alone should not be regarded as a contraindication to invasive management following presentation with NSTEMI.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalActa Cardiologica Sinica
Issue number2
Publication statusPublished - Mar 2013
Externally publishedYes


  • Elderly
  • Invasive strategy
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'The impacts of in-hospital invasive strategy on long-term outcome in elderly patients with non-ST-elevation myocardial infarction'. Together they form a unique fingerprint.

Cite this