Previously, we reported a novel 12-mer peptide binding to hepatocellular carcinoma (HCC) cells specifically and sensitively, and it was screened by using a phage displayed peptide library. To identify the potential of this peptide to be used to the early diagnosis and drug delivery of HCC clinic, the synthesized peptide probe was further characterized by using the assays of cell immunofluorescence and tissue chip. The results of cultured cell immunofluorescence assay show that the peptide probe binds to HCC cells with satisfactory specificity and sensitivity. The results of tissue chip show that the peptide probe can bind to the most common types of HCC tissues, especially to the HCC tissues differentiated at grade II. All further characterized results indicate that this peptide is of the great potential to be used as a HCC targeting candidate for the early molecular imaging diagnosis and targeting nanoparticle or drug delivery in HCC clinic practice.
|Journal||Biomedical Engineering - Applications, Basis and Communications|
|Publication status||Published - Dec 25 2014|
- Hepatocellular carcinoma
- Specific peptide
- Targeting diagnosis and therapy
ASJC Scopus subject areas
- Biomedical Engineering