The expression pattern of SEPT7 correlates with sperm morphology

Hsin Chih Albert Chao, Ying Hung Lin, Yung Che Kuo, Chiung Jiung Shen, Hsian Ann Pan, Pao Lin Kuo

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Purpose: To investigate the expression pattern of the SEPT7 protein during spermatogenesis and its potential role in sperm function. Methods: We first investigated the expression pattern of SEPT7 during different steps of mouse spermiogenesis using an immunofluorescence assay (IFA). IFA was also applied to study the expression pattern of SEPT7 in human ejaculated spermatozoa. Nine fertile men with normal semen parameters were used as the control group, and 21 infertile men with asthenozoospermia were recruited as the patient group. We assessed the frequency of the SEPT7 signal in the various morphological subgroups. Results: In humans, the frequency of a defective SEPT7 signal was significantly increased in men with asthenozoospermia. The absence of a SEPT7 signal was more prevalent in sperm containing morphological defects of various types. Conclusions: The expression pattern of SEPT7 suggested that this protein may be involved in the regulation of subcellular-compartment formation during spermiogenesis in the mouse. The absence of a SEPT7 signal correlated with multiple sperm defects.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalJournal of Assisted Reproduction and Genetics
Issue number6
Publication statusPublished - Jun 1 2010
Externally publishedYes


  • Compartmentalization
  • Expression pattern
  • SEPT7
  • Sperm morphology
  • Spermiogenesis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)
  • General Medicine


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