The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study

Po Lin Chiang; Wen Rui Hao; Hong Jye Hong; Chun Chao Chen; Chun Chih Chiu; Yu Ann Fang; Tsung Lin Yang; Yu Hsin Lai; Ming Yao Chen; Min Huei Hsu; Kuan Rau Chiou; Kuan Jie Lin; Tsung Yeh Yang; Hsin Hsiu; Ju Chi Liu

doi:10.3390/cancers15194728

The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study

Po Lin Chiang, Wen Rui Hao, Hong Jye Hong, Chun Chao Chen, Chun Chih Chiu, Yu Ann Fang, Tsung Lin Yang, Yu Hsin Lai, Ming Yao Chen, Min Huei Hsu, Kuan Rau Chiou, Kuan Jie Lin, Tsung Yeh Yang, Hsin Hsiu, Ju Chi Liu

Research output: Contribution to journal › Article › peer-review

Abstract

The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23–1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82–1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31–1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17–1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77–1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.

Original language	English
Article number	4728
Journal	Cancers
Volume	15
Issue number	19
DOIs	https://doi.org/10.3390/cancers15194728
Publication status	Published - Oct 2023

Keywords

colorectal cancer
insomnia
malignancy
sleep apnea
sleep disorder

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers15194728

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Chiang, P. L., Hao, W. R., Hong, H. J., Chen, C. C., Chiu, C. C., Fang, Y. A., Yang, T. L., Lai, Y. H., Chen, M. Y., Hsu, M. H., Chiou, K. R., Lin, K. J., Yang, T. Y., Hsiu, H., & Liu, J. C. (2023). The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study. Cancers, 15(19), Article 4728. https://doi.org/10.3390/cancers15194728

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title = "The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study",

abstract = "The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23–1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82–1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31–1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17–1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77–1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.",

keywords = "colorectal cancer, insomnia, malignancy, sleep apnea, sleep disorder",

author = "Chiang, {Po Lin} and Hao, {Wen Rui} and Hong, {Hong Jye} and Chen, {Chun Chao} and Chiu, {Chun Chih} and Fang, {Yu Ann} and Yang, {Tsung Lin} and Lai, {Yu Hsin} and Chen, {Ming Yao} and Hsu, {Min Huei} and Chiou, {Kuan Rau} and Lin, {Kuan Jie} and Yang, {Tsung Yeh} and Hsin Hsiu and Liu, {Ju Chi}",

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year = "2023",

month = oct,

doi = "10.3390/cancers15194728",

language = "English",

volume = "15",

journal = "Cancers",

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AU - Chiang, Po Lin

AU - Hao, Wen Rui

AU - Hong, Hong Jye

AU - Chen, Chun Chao

AU - Chiu, Chun Chih

AU - Fang, Yu Ann

AU - Yang, Tsung Lin

AU - Lai, Yu Hsin

AU - Chen, Ming Yao

AU - Hsu, Min Huei

AU - Chiou, Kuan Rau

AU - Lin, Kuan Jie

AU - Yang, Tsung Yeh

AU - Hsiu, Hsin

AU - Liu, Ju Chi

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AB - The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23–1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82–1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31–1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17–1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77–1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.

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KW - insomnia

KW - malignancy

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ER -

The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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